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AM-0883 , CAS No.A607569, Activator of TRPC6

Item Number

A607569

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SKU	Size	Availability	Price	Qty
A607569-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607569-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(5-chlorospiro[1,2-dihydroindole-3,4'-piperidine]-1'-yl)-[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methanone
INCHI	InChI=1S/C21H21ClN2O3/c22-14-5-6-16-15(11-14)21(13-23-16)7-9-24(10-8-21)20(25)19-12-26-17-3-1-2-4-18(17)27-19/h1-6,11,19,23H,7-10,12-13H2/t19-/m1/s1
InChi Key	BXICOOMUFFWMCC-LJQANCHMSA-N
Canonical SMILES	ClC1=CC=C2NCC3(CCN(CC3)C(=O)[C@H]4COC5=C(O4)C=CC=C5)C2=C1
PubChem CID	145997911

PubChem CID	145997911
RCSB PDB Ligand	R0D

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1. Yang PL, Li XH, Wang J, Ma XF, Zhou BY, Jiao YF, Wang WH, Cao P, Zhu MX, Li PW et al.. (2021) GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.. J Biol Chem, 297 (4): (101125). [PMID:34461094]
2. Bai Y, Yu X, Chen H, Horne D, White R, Wu X, Lee P, Gu Y, Ghimire-Rijal S, Lin DC et al.. (2020) Structural basis for pharmacological modulation of the TRPC6 channel.. Elife, 9 (3): (589-97). [PMID:32149605]

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