AM 114 - ≥97%(HPLC), high purity , CAS No.856849-35-9

  • ≥97%(HPLC)
Item Number
A287890
Grouped product items
SKUSizeAvailabilityPrice Qty
A287890-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$59.90
A287890-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$98.90
A287890-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$197.90
A287890-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$345.90
A287890-100mg
100mg
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$573.90
A287890-250mg
250mg
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,291.90

20S proteasome inhibitor

Basic Description

Synonyms3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one;[4-[(Z)-[(5Z)-5-[(4-boronophenyl)methylidene]-1-methyl-4-oxopiperidin-3-ylidene]methyl]phenyl]boronic acid
Specifications & Purity≥97%(HPLC)
Biochemical and Physiological MechanismsInhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50~ 1μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50= 1.49μM).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

HeLa 62764 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Names and Identifiers

IUPAC Name [4-[(E)-[(5E)-5-[(4-boronophenyl)methylidene]-1-methyl-4-oxopiperidin-3-ylidene]methyl]phenyl]boronic acid
INCHI InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10+,17-11+
InChi Key SRPIKXGUPAKTIZ-OTYYAQKOSA-N
Canonical SMILES B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O
Isomeric SMILES B(O)(O)C1=CC=C(C=C1)/C=C\2/C(=O)/C(=C/C3=CC=C(C=C3)B(O)O)/CN(C2)C
PubChem CID 11639443
Molecular Weight 377.01

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
E23151016Certificate of AnalysisMar 30, 2023 A287890
E23151017Certificate of AnalysisMar 30, 2023 A287890
E23151018Certificate of AnalysisMar 30, 2023 A287890
E2315975Certificate of AnalysisMar 30, 2023 A287890
E2315984Certificate of AnalysisMar 30, 2023 A287890
E2315985Certificate of AnalysisMar 30, 2023 A287890

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 3.77, Max Conc. mM: 10

Related Documents

Solution Calculators