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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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A287890-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $59.90 | |
A287890-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $98.90 | |
A287890-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $197.90 | |
A287890-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $345.90 | |
A287890-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $573.90 | |
A287890-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,291.90 |
20S proteasome inhibitor
Synonyms | 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one;[4-[(Z)-[(5Z)-5-[(4-boronophenyl)methylidene]-1-methyl-4-oxopiperidin-3-ylidene]methyl]phenyl]boronic acid |
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Specifications & Purity | ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50~ 1μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50= 1.49μM). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | [4-[(E)-[(5E)-5-[(4-boronophenyl)methylidene]-1-methyl-4-oxopiperidin-3-ylidene]methyl]phenyl]boronic acid |
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INCHI | InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10+,17-11+ |
InChi Key | SRPIKXGUPAKTIZ-OTYYAQKOSA-N |
Canonical SMILES | B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O |
Isomeric SMILES | B(O)(O)C1=CC=C(C=C1)/C=C\2/C(=O)/C(=C/C3=CC=C(C=C3)B(O)O)/CN(C2)C |
PubChem CID | 11639443 |
Molecular Weight | 377.01 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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E23151016 | Certificate of Analysis | Mar 30, 2023 | A287890 |
E23151017 | Certificate of Analysis | Mar 30, 2023 | A287890 |
E23151018 | Certificate of Analysis | Mar 30, 2023 | A287890 |
E2315975 | Certificate of Analysis | Mar 30, 2023 | A287890 |
E2315984 | Certificate of Analysis | Mar 30, 2023 | A287890 |
E2315985 | Certificate of Analysis | Mar 30, 2023 | A287890 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 3.77, Max Conc. mM: 10 |
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