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AM-6538 - 99%, high purity , CAS No.1245626-00-9

  • ≥99%
Item Number
A649958
Grouped product items
SKUSizeAvailabilityPrice Qty
A649958-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$450.90
A649958-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$690.90
A649958-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,380.90

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsAM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability

In Vitro

AM6538 is a cannabinoid antagonist that binds CB1 receptors expressed in HEK-293 cells in a wash-resistant manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AM6538 (1~10 mg/kg) antagonizes the antinociceptive effects of cannabinoid agonists in mice . AM6538 (10 mg/kg) shows that there are some recovery in the effects of AM4054. AM6538 dose dependently decreases the tau values for all cannabinoid agonists, reflecting reductions in the available receptors. AM6538 produces enduring antagonism, with robust effects on the tetrahydrocannabinol dose-effect function evident up to 7 days after treatment . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:cannabinoid

Names and Identifiers

Canonical SMILES O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CCCO[N+]([O-])=O)C=C3)=C1C)NN4CCCCC4
Molecular Weight 542.41

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilityDMSO : 50 mg/mL (92.18 mM; Need ultrasonic)

Related Documents

Solution Calculators