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AM1710 , CAS No.A607576, Agonist of CB 1 receptor;Agonist of CB 2 receptor

  • Moligand™
Item Number
A607576
Grouped product items
SKUSizeAvailabilityPrice Qty
A607576-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
A607576-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90

Basic Description

SynonymsAM-1710|R0GPP0WDF9|3-(1,1-Dimethylheptyl)-1-hydroxy-9-methoxy-6H-dibenzo(b,d)pyran-6-one|UNII-R0GPP0WDF9|AM1710|335371-36-3|CHEMBL266712|6H-Dibenzo(b,d)pyran-6-one, 3-(1,1-dimethylheptyl)-1-hydroxy-9-methoxy-|1-hydroxy-9-methoxy-3-(2-methyloctan-2-yl)benz
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of CB 1 receptor;Agonist of CB 2 receptor

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNR2 Tchem Cannabinoid receptor 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-hydroxy-9-methoxy-3-(2-methyloctan-2-yl)benzo[c]chromen-6-one
INCHI InChI=1S/C23H28O4/c1-5-6-7-8-11-23(2,3)15-12-19(24)21-18-14-16(26-4)9-10-17(18)22(25)27-20(21)13-15/h9-10,12-14,24H,5-8,11H2,1-4H3
InChi Key ZAIKPEWFCSQNQB-UHFFFAOYSA-N
Canonical SMILES CCCCCCC(c1cc(O)c2c(c1)oc(=O)c1c2cc(OC)cc1)(C)C
Isomeric SMILES CCCCCCC(C)(C)C1=CC(=C2C(=C1)OC(=O)C3=C2C=C(C=C3)OC)O
PubChem CID 11268660

Certificates

Certificate of Analysis(COA)

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Related Documents

References

1. Bingham B, Jones PG, Uveges AJ, Kotnis S, Lu P, Smith VA, Sun SC, Resnick L, Chlenov M, He Y et al..  (2007)  Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers..  Br J Pharmacol,  151  (7): (1061-70).  [PMID:17549048]
2. Khanolkar AD, Lu D, Ibrahim M, Duclos Jr RI, Thakur GA, Malan Jr TP, Porreca F, Veerappan V, Tian X, George C et al..  (2007)  Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity..  J Med Chem,  50  (26): (6493-500).  [PMID:18038967]
3. Rahn EJ, Thakur GA, Wood JA, Zvonok AM, Makriyannis A, Hohmann AG.  (2011)  Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects..  Pharmacol Biochem Behav,  98  (4): (493-502).  [PMID:21382397]
4. Dhopeshwarkar A, Murataeva N, Makriyannis A, Straiker A, Mackie K.  (2017)  Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists..  J Pharmacol Exp Ther,  360  (2): (300-311).  [PMID:27927913]
5. Li AL, Lin X, Dhopeshwarkar AS, Thomaz AC, Carey LM, Liu Y, Nikas SP, Makriyannis A, Mackie K, Hohmann AG.  (2019)  Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal..  Mol Pharmacol,  95  (2): (155-168).  [PMID:30504240]

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