AM281 - 98%, high purity , CAS No.202463-68-1, Antagonist of CB 1 receptor;Antagonist of GPR55

Item Number

A607581

• Synonyms: AM 281|1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice. Potent and selective CB1 cannabinoid receptor antagonist/
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of CB 1 receptor;Antagonist of GPR55

Product Description

AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM。 

Application：

AM281 has been used as a cannabinoid 1 receptor antagonist:
to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice
to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments
to study its effect on scopolamine-induced memory deficit using object recognition paradigm
to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain