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AM404 - 98%, high purity , CAS No.183718-77-6, Inhibitor of TRPV4

Moligand™
≥98%

CAS#: 183718-77-6
Formula: C₂₆H₃₇NO₂
Molecular Weight: 395.58
PubChem CID: 6604822

Item Number

A607584

Grouped product items
SKU	Size	Availability	Price
A607584-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
A607584-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$124.90
A607584-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$279.90
A607584-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90
A607584-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$899.90

View related series

Cannabinoid Transporter Inhibitors Cannabinoid Transporters Neurotransmitter Transporters Pharmacology Transporters TRPV4 Inhibitor

Basic Description

Synonyms	am404 \| AM-404 \| CPD000449274 \| Q4652517 \| CS-0021276 \| N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide \| CHEBI:197140 \| STK760084 \| DC34415 \| AM 404 \| NC00006 \| HMS2051K03 \| Tocris-1116 \| UNII-XVJ94H0U21 \| (5Z,8Z)-Icosa-5,8,11,14-tetraenoic acid (4-hyd
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	AM 404 is a competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Al
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TRPV4
Product Description	AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 µM). Neuroprotective Effect.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid receptor 1 0 Activities

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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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CNR2 Tchem Cannabinoid receptor 2 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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EYA2 Tbio Eyes absent homolog 2 0 Activities

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CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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PSMB5 Tclin Proteasome subunit beta type-5 0 Activities

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PSMB11 Tbio Proteasome subunit beta type-11 0 Activities

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

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FTL Tbio Ferritin light chain 0 Activities

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KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

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TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 0 Activities

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TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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GAA Tclin Lysosomal alpha-glucosidase 0 Activities

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ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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MAPT Tclin Microtubule-associated protein tau 0 Activities

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TP53 Tchem Cellular tumor antigen p53 0 Activities

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NPSR1 Tchem Neuropeptide S receptor 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
INCHI	InChI=1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15-
InChi Key	IJBZOOZRAXHERC-DOFZRALJSA-N
Canonical SMILES	CCCCCC=CCC=CCC=CCC=CCCCC(=O)NC1=CC=C(C=C1)O
Isomeric SMILES	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NC1=CC=C(C=C1)O
WGK Germany	2
Alternate CAS	198022-70-7
PubChem CID	6604822
Molecular Weight	395.58

PubChem CID

6604822

ChEMBL Ligand

CHEMBL39878

Sensitivity

air sensitive

Flash Point(°F)

57.2 °F

Flash Point(°C)

14 °C

Pictogram(s)

GHS02

Signal

Danger

Hazard Statements

H225:Highly Flammable liquid and vapor

Precautionary Statements

P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking.

WGK Germany

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