Potent and selective CXCR4 antagonist. Shows 8-fold greater affinity than AMD 3100 . Potent HIV entry inhibitor (IC 50 = ~10 nM). Additionally mobilizes stem cells in vivo .
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Hatse S et al.. (2005) AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.. Biochem Pharmacol, 70 (5):(752-61). [PMID:16011832]
2.Hu JS et al.. (2006) AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation.. Am J Pathol, 169 (2):(424-32). [PMID:16877345]
3.Bodart V et al.. (2009) Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.. Biochem Pharmacol, 78 (8):(993-1000). [PMID:19540208]
4.Forte D et al.. (2017) The tissue inhibitor of metalloproteinases-1 (TIMP-1) promotes survival and migration of acute myeloid leukemia cells through CD63/PI3K/Akt/p21 signaling.. Oncotarget, 8 (2):(2261-2274). [PMID:27903985]
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