Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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A276243-5mg | 5mg | In stock | $112.90 | |
A276243-10mg | 10mg | In stock | $147.90 | |
A276243-25mg | 25mg | In stock | $333.90 | |
A276243-50mg | 50mg | In stock | $591.90 | |
A276243-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,045.90 |
Potent, selective, competitive vanilloid TRPV1 receptor antagonist
Synonyms | 545395-94-6|AMG 9810|AMG9810|AMG-9810|(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide|182HIJ2D7F|CHEMBL195789|C21H23NO3|(E)-3-(4-(tert-butyl)phenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide|3-(4-t-butylphen |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties. AMG 9810 is a |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | CHANNEL BLOCKER |
Mechanism of action | Channel blocker of TRPV1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide |
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INCHI | InChI=1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+ |
InChi Key | GZTFUVZVLYUPRG-IZZDOVSWSA-N |
Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC2=CC3=C(C=C2)OCCO3 |
Isomeric SMILES | CC(C)(C)C1=CC=C(C=C1)/C=C/C(=O)NC2=CC3=C(C=C2)OCCO3 |
PubChem CID | 680502 |
Molecular Weight | 337.42 |
PubChem CID | 680502 |
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CAS Registry No. | 545395-94-6 |
ChEMBL Ligand | CHEMBL195789 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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L2122337 | Certificate of Analysis | Jul 12, 2023 | A276243 |
L2122338 | Certificate of Analysis | Jul 12, 2023 | A276243 |
L2122339 | Certificate of Analysis | Jul 12, 2023 | A276243 |
L2122340 | Certificate of Analysis | Jul 12, 2023 | A276243 |
L2122341 | Certificate of Analysis | Jul 12, 2023 | A276243 |
Solubility | Soluble in ethanol to 100 mM and in DMSO to 100 mM |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H413:May cause long lasting harmful effects to aquatic life H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |