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AMG PERK 44 - 95%, high purity , CAS No.1883548-84-2

  • ≥95%
Item Number
A286749
Grouped product items
SKUSizeAvailabilityPrice Qty
A286749-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$66.90
A286749-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$198.90
A286749-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$317.90
A286749-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$635.90
A286749-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90
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Potent and selective PERK inhibitor

View related series
Autophagy Cell Cycle/DNA Damage PERK

Basic Description

Synonyms4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
Specifications & Purity95%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

AMG PERK 44 is an orally effective, highly selective PERK inhibitor with an IC50 of 6 nM. The selectivity of AMG PERK 44 for PERK is 1000 and 160 times higher than that of GCN2 (IC50=7300 nM) and B-Raf (IC50>1000 nM), respectively. AMG PERK 44 can induce autophagy.

Names and Identifiers

IUPAC Name 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride
INCHI InChI=1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/h4-20H,35H2,1-3H3;1H
InChi Key RNAKBTDDCHJCMT-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl
PubChem CID 121513867
Molecular Weight 561.07

Certificates

Certificate of Analysis(COA)

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9 results found

Lot NumberCertificate TypeDateItem
H2429045Certificate of AnalysisMay 22, 2024 A286749
H2429046Certificate of AnalysisMay 22, 2024 A286749
H2429047Certificate of AnalysisMay 22, 2024 A286749
H2429048Certificate of AnalysisMay 22, 2024 A286749
H2429049Certificate of AnalysisMay 22, 2024 A286749
H2429050Certificate of AnalysisMay 22, 2024 A286749
H2429051Certificate of AnalysisMay 22, 2024 A286749
H2429052Certificate of AnalysisMay 22, 2024 A286749
H2429179Certificate of AnalysisMay 22, 2024 A286749

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 11.22, Max Conc. mM: 20
SensitivityMoisture sensitive

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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