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Aminohexylgeldanamycin - 99%, high purity , CAS No.485395-71-9
Basic Description Specifications & Purity 99% Storage Temp Protected from light,Store at -20°C Shipped In Ice chest + Ice pads Product Description Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities
In Vitro
HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:HSP90
Names and Identifiers IUPAC Name [(4Z,6Z,10Z)-19-(6-aminohexylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate INCHI InChI=1S/C34H52N4O8/c1-20-16-24-29(37-15-10-8-7-9-14-35)26(39)19-25(31(24)41)38-33(42)21(2)12-11-13-27(44-5)32(46-34(36)43)23(4)18-22(3)30(40)28(17-20)45-6/h11-13,18-20,22,27-28,30,32,37,40H,7-10,14-17,35H2,1-6H3,(H2,36,43)(H,38,42)/b13-11-,21-12-,23-18- InChi Key FEKZHEHNADINKB-YIAZIGALSA-N Canonical SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCCCCCN)C)OC)OC(=O)N)C)C)O)OC PubChem CID 167995159 Molecular Weight 644.80
Chemical and Physical Properties Solubility DMSO : 110 mg/mL (170.60 mM; Need ultrasonic)
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