Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A413377-25mg | 25mg | In stock | $58.90 | |
A413377-100mg | 100mg | In stock | $126.90 | |
A413377-500mg | 500mg | In stock | $499.90 |
Histamine Receptor Inhibitors
Synonyms | amitriptyline|50-48-6|Damitriptyline|Amitriptylin|Triptanol|Flavyl|Seroten|Proheptadiene|Elavil|Lantron|Triptisol|Tryptanol|Adepress|Adepril|Damilen|Amitryptiline|Triptilin|Redomex|Amitriprolidine|Laroxyl|Amytriptylin|Amitriptilina|Amitriptylinum|Amitrypt |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter ( |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST, CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Antagonist of 5-HT 7 receptor;Antagonist of H 1 receptor;Channel blocker of K ir3.2;Channel blocker of K ir3.4;Antagonist of LPA 1 receptor;Antagonist of M 1 recep |
Product Description |
Amitriptyline is a common oral anticholinergic. Amitriptyline has anticholinergic properties. Amitriptyline can be used to quantify anticholinergic adverse reactions in patients taking amitriptyline and placebo.Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine rece
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IUPAC Name | N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine |
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INCHI | InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 |
InChi Key | KRMDCWKBEZIMAB-UHFFFAOYSA-N |
Canonical SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
Isomeric SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
PubChem CID | 2160 |
Molecular Weight | 277.41 |
PubChem CID | 2160 |
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DrugBank Ligand | DB00321 |
CAS Registry No. | 50-48-6 |
ChEBI | CHEBI:2666 |
Wikipedia | Amitriptyline |
ChEMBL Ligand | CHEMBL629 |
BindingDB Ligand | 50020712 |
RCSB PDB Ligand | TP0 |
PEP | amitriptyline |
DrugCentral Ligand | 180 |
GPCRdb Ligand | amitriptyline |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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B2429116 | Certificate of Analysis | Feb 04, 2024 | A413377 |
B2429117 | Certificate of Analysis | Feb 04, 2024 | A413377 |
E2407085 | Certificate of Analysis | Feb 04, 2024 | A413377 |
B2420028 | Certificate of Analysis | Jul 18, 2022 | A413377 |
H2220138 | Certificate of Analysis | Jul 18, 2022 | A413377 |
H2220139 | Certificate of Analysis | Jul 18, 2022 | A413377 |
H2220140 | Certificate of Analysis | Jul 18, 2022 | A413377 |
Solubility | Solubility (25°C) In vitro |
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Sensitivity | light sensitive |
Pictogram(s) | GHS06, GHS08, GHS09, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H318:Causes serious eye damage H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child H301+H311+H331:Toxic if swallowed, in contact with skin or if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P316:Get emergency medical help immediately. |