Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor.It functions as a chelating agent, which allows the preconcentration of trace metals from solution.Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells
1.Zhang R et al.. (2018) A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid Arthritis.. Sci Rep, 8 (2623). [PMID:29422529]
2.Niu J et al.. (2017) Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12and P2Y13receptors in neuropathic pain rats.. J Neuroinflammation, 14 (185). [PMID:28899427]
3.Jin X et al.. (2015) Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-?B Pathway.. Biomed Res Int, 2015 (732450). [PMID:26114112]
4.Nam JE et al.. (2020) Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.. Life Sci, 254 (117742). [PMID:32360619]
5.McIlwain DW et al.. (2018) APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells.. Oncotarget, 9 (13):(10962-10977). [PMID:29541389]
6.Ding L et al.. (2020) CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.. Stem Cells, 38 (2):(261-275). [PMID:31721342]
7.Wang JB et al.. (2022) CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.. Cancer Gene Ther, [PMID:35999359]
8.Zhang T et al.. (2020) Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.. Front Cell Dev Biol, 8 (784). [PMID:32903542]
9.Yao L et al.. (2019) Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-ß1/SMADS/AMPK/NF-?B pathways.. BMC Complement Altern Med, 19 (14). [PMID:30630477]
10.Wang Q et al.. (2017) HMGB1 induces lung fibroblast to myofibroblast differentiation through NF-?B-mediated TGF-ß1 release.. Mol Med Rep, 15 (5):(3062-3068). [PMID:28339089]
11.Lang J et al.. (2016) Modeling Dengue Virus-Hepatic Cell Interactions Using Human Pluripotent Stem Cell-Derived Hepatocyte-like Cells.. Stem Cell Reports, 7 (3):(341-54). [PMID:27546535]
12.Zhou Z et al.. (2016) Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NF?B Pathway Suppression.. J Diabetes Res, 2016 (4847812). [PMID:27761470]
13.Xu X et al.. (2018) Phosphorylation-Mediated IFN-?R2 Membrane Translocation Is Required to Activate Macrophage Innate Response.. Cell, 175 (5):(1336-1351.e17). [PMID:30318148]
14.Jin X et al.. (2016) Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation.. FEBS J, 283 (12):(2295-308). [PMID:27062545]
15.Jiang H et al.. (2017) Proprotein convertase subtilisin/kexin type 6 promotes in\xa0vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-?B, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathways.. Mol Med Rep, 16 (6):(8477-8484). [PMID:28944919]
16.Song Y et al.. (2020) Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-?B pathway.. Folia Neuropathol, 58 (2):(166-175). [PMID:32729295]
17.Jiang N et al.. (2017) Toll-like receptor 4 promotes proliferation and apoptosis resistance in human papillomavirus-related cervical cancer cells through the Toll-like receptor 4/nuclear factor-?B pathway.. Tumour Biol, 39 (6):(1010428317710586). [PMID:28653898]
18.Sun L et al.. (2019) The involvement of spinal annexin A10/NF-?B/MMP-9 pathway in the development of neuropathic pain in rats.. BMC Neurosci, 20 (28). [PMID:31208343]
19.Tazawa K et al.. (2020) Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization.. Am J Pathol, 190 (12):(2417-2426). [PMID:32919979]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
D2029038
