| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A424399-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Selective NF-κB inhibitor; antioxidant
| Synonyms | 5108-96-3|Ammonium pyrrolidinedithiocarbamate|Ammonium pyrrolidine-1-carbodithioate|Pyrrolidinedithiocarbamate ammonium|apdc|1-Pyrrolidinecarbodithioic acid ammonium salt|PDTC|Ammonium 1-Pyrrolidinedithiocarbamate|Ammonium 1-pyrrolidinecarbodithioate|1-Py |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt is a potent inhibitor of NF κB (Nuclear Factor κB). Experiments show that micromolar amounts of this compound suppress IL-1β and completely inhibit the increase of nitric oxide synthase mRNA in response |
| Storage Temp | Store at -80°C |
| Shipped In | Dry ice |
| Product Description | Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor.It functions as a chelating agent, which allows the preconcentration of trace metals from solution.Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells |
| IUPAC Name | azanium;pyrrolidine-1-carbodithioate |
|---|---|
| INCHI | InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3 |
| InChi Key | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
| Canonical SMILES | C1CCN(C1)C(=S)[S-].[NH4+] |
| Isomeric SMILES | C1CCN(C1)C(=S)[S-].[NH4+] |
| WGK Germany | 3 |
| PubChem CID | 517348 |
| Molecular Weight | 164.29 |
| Beilstein | 3730472 |
| Reaxy-Rn | 3730472 |
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| Sensitivity | Air and heat sensitive、Hygroscopic |
|---|---|
| Melt Point(°C) | 149-152°C |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 3730472 |
