| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A424399-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Selective NF-κB inhibitor; antioxidant
| Synonyms | 5108-96-3 | Ammonium pyrrolidinedithiocarbamate | Ammonium pyrrolidine-1-carbodithioate | Pyrrolidinedithiocarbamate ammonium | apdc | 1-Pyrrolidinecarbodithioic acid ammonium salt | PDTC | Ammonium 1-Pyrrolidinedithiocarbamate | Ammonium 1-pyrrolidinecarbodithioate | 1-Py |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt is a potent inhibitor of NF κB (Nuclear Factor κB). Experiments show that micromolar amounts of this compound suppress IL-1β and completely inhibit the increase of nitric oxide synthase mRNA in response |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor.It functions as a chelating agent, which allows the preconcentration of trace metals from solution.Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells |
| IUPAC Name | azanium;pyrrolidine-1-carbodithioate |
|---|---|
| INCHI | InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3 |
| InChi Key | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
| Canonical SMILES | C1CCN(C1)C(=S)[S-].[NH4+] |
| Isomeric SMILES | C1CCN(C1)C(=S)[S-].[NH4+] |
| WGK Germany | 3 |
| PubChem CID | 517348 |
| Molecular Weight | 164.29 |
| Beilstein | 3730472 |
| Reaxy-Rn | 3730472 |
Enter Lot Number to search for COA:
| Sensitivity | Air and heat sensitive、Hygroscopic |
|---|---|
| Melt Point(°C) | 149-152°C |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 3730472 |
| 1. Yujing He, Jing Hu, Wei Zou, Hanjiao Chen, Xiaoming Jiang, Xiandeng Hou. (2023) Chemical vapor generation of tungsten for atomic spectrometric determination: Homogeneous sensitizer and mechanism study. ANALYTICA CHIMICA ACTA, 1278 (341746). [PMID:37709475] [10.1016/j.aca.2023.341746] |
| 2. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu. (2023) Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis. ACS Omega, [PMID:37663478] [10.1021/acsomega.3c04724] |
| 3. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du. (2023) An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO. CHEMICAL ENGINEERING JOURNAL, 471 (144797). [PMID:] [10.1016/j.cej.2023.144797] |
| 4. Haotian Zhang, Ziyun Wei, Yichen Tong, Xiuping Song, Siyue Li, Yuanfang Sun, Chun Liu, Fei Han, Jia Yu. (2023) Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage. JOURNAL OF ETHNOPHARMACOLOGY, 314 (116628). [PMID:37196817] [10.1016/j.jep.2023.116628] |
| 5. Yafei Zhen, Tao Lin, Hanjiao Chen, Jing Hu, Xiandeng Hou. (2022) Vapor Generation of Rare-Earth Elements via Reaction with Tetrahydroborate: Chemical Identities and Mechanisms of Formation. ANALYTICAL CHEMISTRY, 94 (44): (15176–15182). [PMID:36301518] [10.1021/acs.analchem.2c01486] |
| 6. Chao Li, Linna Duan, Mingchao Han, Hongwei He, Mengxiang Yuan, Hairong Wang. (2022) A Chelating Resin of EDTA-Type Modified Cross-Linking Polystyrene to Preconcentrate Trace Metals for Seawater Detection. Journal of Analytical Methods in Chemistry, 2022 (2080600). [PMID:36275429] [10.1155/2022/2080600] |
| 7. Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du, Hongqiang Song. (2022) Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics. Bioengineered, 13 (4): (9839-9854). [PMID:35436417] [10.1080/21655979.2022.2061288] |
| 8. Caizhen Liang, Xiaobao Xie, Dandan Zhang, Jin Feng, Shunying Lu, Qingshan Shi. (2021) Biomass carbon dots derived from Wedelia trilobata for the direct detection of glutathione and their imaging application in living cells. Journal of Materials Chemistry B, 9 (28): (5670-5681). [PMID:34195715] [10.1039/D0TB02979C] |
| 9. Jingli Zhang, Lingling Zhu, Hong Shi, Huizhe Zheng. (2021) Protective effects of miR‑155‑5p silencing on IFN‑γ‑induced apoptosis and inflammation in salivary gland epithelial cells. Experimental and Therapeutic Medicine, 22 (2): (1-11). [PMID:34194560] [10.3892/etm.2021.10314] |
| 10. Jia Qinghui, Zhang Haihua, Su Yongmei, Liu Xin, Bai Jiangsong, Lang Wuying, Shi Qiumei, Feng Minshan. (2021) Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 77 (2): (283-294). [PMID:33595775] [10.1007/s13105-021-00796-y] |
| 11. Wang Wanyue, Li Xin, Xu Ye, Guo Weikang, Yu Hui, Zhang Lu, Wang Yaoxian, Chen Xiuwei. (2021) Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB. CELLULAR ONCOLOGY, 44 (3): (557-568). [PMID:33469837] [10.1007/s13402-020-00582-w] |
| 12. Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang. (2021) Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. BIOMATERIALS, 268 (120579). [PMID:33278683] [10.1016/j.biomaterials.2020.120579] |
| 13. Shiwei Yang, Yihuan Song, Qingfang Ma, Heyong Cheng, Yuanchao Wang, Jinhua Liu. (2020) Quantification of ultra-trace organolead species in environmental water by inductively coupled plasma mass spectrometry with online solid-phase extraction and high performance liquid chromatographic separation. ANALYTICA CHIMICA ACTA, 1133 (30). [PMID:32993871] [10.1016/j.aca.2020.07.046] |
| 14. Wei Zou, Chenghui Li, Jing Hu, Xiandeng Hou. (2020) Selective determination of Cr(Ⅵ) and non-chromatographic speciation analysis of inorganic chromium by chemical vapor generation-inductively coupled plasma mass spectrometry. TALANTA, 218 (121128). [PMID:32797885] [10.1016/j.talanta.2020.121128] |
| 15. Yuxi Lu, Xuelu Gao, Chen-Tung Arthur Chen. (2019) Separation and determination of colloidal trace metals in seawater by cross-flow ultrafiltration, liquid-liquid extraction and ICP-MS. MARINE CHEMISTRY, 215 (103685). [PMID:] [10.1016/j.marchem.2019.103685] |
| 16. Jinrong Lu, Xiaonan Wu, Yao Li, Wenquan Cui, Yinghua Liang. (2018) Modified silica gel surface with chelating ligand for effective mercury ions adsorption. Surfaces and Interfaces, 12 (108). [PMID:] [10.1016/j.surfin.2018.04.005] |
| 17. Linlin Lu, Chongchong Feng, Jie Xu, Fengyang Wang, Haijun Yu, Zhiai Xu, Wen Zhang. (2017) Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells. BIOSENSORS & BIOELECTRONICS, 92 (101). [PMID:28193561] [10.1016/j.bios.2017.01.066] |
| 18. Xiaojun Wang, Guoliang Xu, Peng Chen, Xueying Liu, Ye Fang, Siyu Yang, Guozhen Wang. (2016) Arsenic speciation analysis in environmental water, sediment and soil samples by magnetic ionic liquid-based air-assisted liquid–liquid microextraction. RSC Advances, 6 (111): (110247-110254). [PMID:] [10.1039/C6RA21199B] |
| 19. Xiaojun Wang, Long Wu, Jiaqi Cao, Xincheng Hong, Rui Ye, Weiji Chen, Ting Yuan. (2016) Magnetic effervescent tablet-assisted ionic liquid dispersive liquid–liquid microextraction of selenium for speciation in foods and beverages. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, [PMID:27181611] [10.1080/19440049.2016.1189807] |
| 1. Yujing He, Jing Hu, Wei Zou, Hanjiao Chen, Xiaoming Jiang, Xiandeng Hou. (2023) Chemical vapor generation of tungsten for atomic spectrometric determination: Homogeneous sensitizer and mechanism study. ANALYTICA CHIMICA ACTA, 1278 (341746). [PMID:37709475] [10.1016/j.aca.2023.341746] |
| 2. Shi Sun, Yifang Wang, Jinhu Li, Ailing Wu, Yan Xie, Zhao Wang, Xinjie Zhao, Dandan Wang, Xiaolong Wu, Xinguang Liu. (2023) Network Pharmacology-Based Approach to Investigate the Active Ingredients and Therapeutic Mechanisms of Jingu Tongxiao Pill against Osteoarthritis. ACS Omega, [PMID:37663478] [10.1021/acsomega.3c04724] |
| 3. Jiancheng Zhang, Congcong Zhang, Yuyang Li, Jingjing Xiao, Yilun Zhang, Min Jia, Lixia Lu, Hongyan Zhang, Jun Zhou, Zhenguo Zhang, Xin Du. (2023) An electrochemical sensing platform for biomonitoring the potential toxicity of plastic particles by detecting NO. CHEMICAL ENGINEERING JOURNAL, 471 (144797). [PMID:] [10.1016/j.cej.2023.144797] |
| 4. Haotian Zhang, Ziyun Wei, Yichen Tong, Xiuping Song, Siyue Li, Yuanfang Sun, Chun Liu, Fei Han, Jia Yu. (2023) Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage. JOURNAL OF ETHNOPHARMACOLOGY, 314 (116628). [PMID:37196817] [10.1016/j.jep.2023.116628] |
| 5. Yafei Zhen, Tao Lin, Hanjiao Chen, Jing Hu, Xiandeng Hou. (2022) Vapor Generation of Rare-Earth Elements via Reaction with Tetrahydroborate: Chemical Identities and Mechanisms of Formation. ANALYTICAL CHEMISTRY, 94 (44): (15176–15182). [PMID:36301518] [10.1021/acs.analchem.2c01486] |
| 6. Chao Li, Linna Duan, Mingchao Han, Hongwei He, Mengxiang Yuan, Hairong Wang. (2022) A Chelating Resin of EDTA-Type Modified Cross-Linking Polystyrene to Preconcentrate Trace Metals for Seawater Detection. Journal of Analytical Methods in Chemistry, 2022 (2080600). [PMID:36275429] [10.1155/2022/2080600] |
| 7. Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du, Hongqiang Song. (2022) Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics. Bioengineered, 13 (4): (9839-9854). [PMID:35436417] [10.1080/21655979.2022.2061288] |
| 8. Caizhen Liang, Xiaobao Xie, Dandan Zhang, Jin Feng, Shunying Lu, Qingshan Shi. (2021) Biomass carbon dots derived from Wedelia trilobata for the direct detection of glutathione and their imaging application in living cells. Journal of Materials Chemistry B, 9 (28): (5670-5681). [PMID:34195715] [10.1039/D0TB02979C] |
| 9. Jingli Zhang, Lingling Zhu, Hong Shi, Huizhe Zheng. (2021) Protective effects of miR‑155‑5p silencing on IFN‑γ‑induced apoptosis and inflammation in salivary gland epithelial cells. Experimental and Therapeutic Medicine, 22 (2): (1-11). [PMID:34194560] [10.3892/etm.2021.10314] |
| 10. Jia Qinghui, Zhang Haihua, Su Yongmei, Liu Xin, Bai Jiangsong, Lang Wuying, Shi Qiumei, Feng Minshan. (2021) Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 77 (2): (283-294). [PMID:33595775] [10.1007/s13105-021-00796-y] |
| 11. Wang Wanyue, Li Xin, Xu Ye, Guo Weikang, Yu Hui, Zhang Lu, Wang Yaoxian, Chen Xiuwei. (2021) Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB. CELLULAR ONCOLOGY, 44 (3): (557-568). [PMID:33469837] [10.1007/s13402-020-00582-w] |
| 12. Changrong Wang, Xiaoguang Shi, Huijuan Song, Chuangnian Zhang, Xiaoli Wang, Pingsheng Huang, Anjie Dong, Yumin Zhang, Deling Kong, Weiwei Wang. (2021) Polymer-lipid hybrid nanovesicle-enabled combination of immunogenic chemotherapy and RNAi-mediated PD-L1 knockdown elicits antitumor immunity against melanoma. BIOMATERIALS, 268 (120579). [PMID:33278683] [10.1016/j.biomaterials.2020.120579] |
| 13. Shiwei Yang, Yihuan Song, Qingfang Ma, Heyong Cheng, Yuanchao Wang, Jinhua Liu. (2020) Quantification of ultra-trace organolead species in environmental water by inductively coupled plasma mass spectrometry with online solid-phase extraction and high performance liquid chromatographic separation. ANALYTICA CHIMICA ACTA, 1133 (30). [PMID:32993871] [10.1016/j.aca.2020.07.046] |
| 14. Wei Zou, Chenghui Li, Jing Hu, Xiandeng Hou. (2020) Selective determination of Cr(Ⅵ) and non-chromatographic speciation analysis of inorganic chromium by chemical vapor generation-inductively coupled plasma mass spectrometry. TALANTA, 218 (121128). [PMID:32797885] [10.1016/j.talanta.2020.121128] |
| 15. Yuxi Lu, Xuelu Gao, Chen-Tung Arthur Chen. (2019) Separation and determination of colloidal trace metals in seawater by cross-flow ultrafiltration, liquid-liquid extraction and ICP-MS. MARINE CHEMISTRY, 215 (103685). [PMID:] [10.1016/j.marchem.2019.103685] |
| 16. Jinrong Lu, Xiaonan Wu, Yao Li, Wenquan Cui, Yinghua Liang. (2018) Modified silica gel surface with chelating ligand for effective mercury ions adsorption. Surfaces and Interfaces, 12 (108). [PMID:] [10.1016/j.surfin.2018.04.005] |
| 17. Linlin Lu, Chongchong Feng, Jie Xu, Fengyang Wang, Haijun Yu, Zhiai Xu, Wen Zhang. (2017) Hydrophobic-carbon-dot-based dual-emission micelle for ratiometric fluorescence biosensing and imaging of Cu2+ in liver cells. BIOSENSORS & BIOELECTRONICS, 92 (101). [PMID:28193561] [10.1016/j.bios.2017.01.066] |
| 18. Xiaojun Wang, Guoliang Xu, Peng Chen, Xueying Liu, Ye Fang, Siyu Yang, Guozhen Wang. (2016) Arsenic speciation analysis in environmental water, sediment and soil samples by magnetic ionic liquid-based air-assisted liquid–liquid microextraction. RSC Advances, 6 (111): (110247-110254). [PMID:] [10.1039/C6RA21199B] |
| 19. Xiaojun Wang, Long Wu, Jiaqi Cao, Xincheng Hong, Rui Ye, Weiji Chen, Ting Yuan. (2016) Magnetic effervescent tablet-assisted ionic liquid dispersive liquid–liquid microextraction of selenium for speciation in foods and beverages. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, [PMID:27181611] [10.1080/19440049.2016.1189807] |
