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Ampalex - ≥95%, high purity , CAS No.154235-83-3, Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

  • Moligand™
  • ≥95%
Item Number
A125747
Grouped product items
SKUSizeAvailabilityPrice Qty
A125747-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$46.90
A125747-100mg
100mg
In stock
$155.90
A125747-500mg
500mg
In stock
$702.90
A125747-1g
1g
In stock
$1,263.90

Basic Description

SynonymsAmpalex|154235-83-3|piperidin-1-yl(quinoxalin-6-yl)methanone|CX516|CX-516|BDP 12|1-(quinoxalin-6-ylcarbonyl)piperidine|1-(6-Quinoxalinylcarbonyl)piperidine|BDP-12|CX 516|Piperidine, 1-(6-quinoxalinylcarbonyl)-|6-(piperidine-1-carbonyl)quinoxaline|173047-7
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsAmpalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). IC50 value: Target: AMPA receptor A
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4
Note500mg、25mg、100mg卖完停产,不再备货
Product Description

CX516 is a positive allosteric modulator at AMPA receptor that inhibits the deactivation of AMPA receptors. CX-516 is a nootropic and ampakine agent
A series of AMPA modulators for the potential treatment of cognitive diseases

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA4 Tclin Glutamate receptor 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488188210
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488188210
IUPAC Name piperidin-1-yl(quinoxalin-6-yl)methanone
INCHI InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
InChi Key ANDGGVOPIJEHOF-UHFFFAOYSA-N
Canonical SMILES C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
Isomeric SMILES C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
RTECS TM2785170
PubChem CID 148184
Molecular Weight 241.29

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
K2211091Certificate of AnalysisAug 22, 2024 A125747
K2211093Certificate of AnalysisAug 22, 2024 A125747
K2211094Certificate of AnalysisAug 22, 2024 A125747
K2211095Certificate of AnalysisAug 22, 2024 A125747
C2302808Certificate of AnalysisMar 14, 2023 A125747
L2219133Certificate of AnalysisJan 10, 2023 A125747
L2219135Certificate of AnalysisJan 10, 2023 A125747
F1807031Certificate of AnalysisFeb 23, 2022 A125747

Chemical and Physical Properties

SolubilityDMSO

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

RTECS TM2785170

Related Documents

Solution Calculators