AN3661 , CAS No.1268335-33-6, Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

Item Number

A607629

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SKU	Size	Availability	Price	Qty
A607629-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607629-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

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Basic Description

Synonyms	1268335-33-6\|3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)propanoic acid\|AN3661\|3-(1-hydroxy-3H-2,1-benzoxaborol-7-yl)propanoic acid\|3-(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-7-yl)propanoic acid\|SCHEMBL1232994\|CHEMBL1643740\|GTPL10084\|CEVOKIPNIZQANN-
Grade	Moligand™
Mechanism of action	Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

Names and Identifiers

IUPAC Name	3-(1-hydroxy-3H-2,1-benzoxaborol-7-yl)propanoic acid
INCHI	InChI=1S/C10H11BO4/c12-9(13)5-4-7-2-1-3-8-6-15-11(14)10(7)8/h1-3,14H,4-6H2,(H,12,13)
InChi Key	CEVOKIPNIZQANN-UHFFFAOYSA-N
Canonical SMILES	OC(=O)CCc1cccc2c1B(O)OC2
Isomeric SMILES	B1(C2=C(CO1)C=CC=C2CCC(=O)O)O
PubChem CID	50898347

ChEMBL Ligand

CAS Registry No.

PubChem CID

References

1. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J, Rosenthal PJ, Waterson D, Gamo FJ, Angulo-Barturen I et al.. (2011) Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.. Bioorg Med Chem Lett, 21 (2): (644-51). [PMID:21195617]
2. Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Ye L, Zhou H, Waterson D, Gamo FJ, Sanz LM et al.. (2012) Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.. Bioorg Med Chem Lett, 22 (3): (1299-307). [PMID:22243961]
3. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ et al.. (2017) A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.. Nat Commun, 8 (3): (14574). [PMID:28262680]

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Basic Description