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Anagrelide HCl - ≥98%, high purity , Phosphodiesterase 3 inhibitor, CAS No.58579-51-4, Phosphodiesterase 3 inhibitor

≥98%

CAS#: 58579-51-4
Formula: C₁₀H₇Cl₂N₃O·HCl
Molecular Weight: 292.55
PubChem CID: 135413494
PubChem SID: 488202861

Item Number

A129685

Grouped product items
SKU	Size	Availability	Price
A129685-50mg	50mg	In stock	$216.90
A129685-250mg	250mg	In stock	$976.90
A129685-1g	1g	In stock	$3,515.90

Potent cAMP PDE-3 inhibitor

Basic Description

Synonyms	ANAGRELIDE HYDROCHLORIDE\|58579-51-4\|Anagrelide HCL\|Agrylin\|Thromboreductin\|Agrelin\|Anagrelide (hydrochloride)\|Anagrelid hydrochlorid\|6,7-Dichloro-5,10-dihydroimidazo[2,1-b]quinazolin-2(3H)-one hydrochloride\|BL 4162A\|Anagrelide hydrochloride [USAN]\|BL-4162
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Anagrelide hydrochloride is a potent PDE3 (type III phosphodiesterase) inhibitor (IC50 = 36 nM). Produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation and inhibits platelet aggregation.Potent cAMP PDE-3 inhibitor (IC 50 = 36
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Phosphodiesterase 3 inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	A potent type III phosphodiesterase inhibitor

Associated Targets

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488202861
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202861
IUPAC Name	6,7-dichloro-3,5-dihydro-1H-imidazo[2,1-b]quinazolin-2-one;hydrochloride
INCHI	InChI=1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
InChi Key	TVWRQCIPWUCNMI-UHFFFAOYSA-N
Canonical SMILES	C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl
Isomeric SMILES	C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl
WGK Germany	3
PubChem CID	135413494
Molecular Weight	292.55

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
C2321451	Certificate of Analysis	Feb 15, 2023	A129685
C2321461	Certificate of Analysis	Feb 15, 2023	A129685
C2321516	Certificate of Analysis	Feb 15, 2023	A129685
C2321567	Certificate of Analysis	Feb 15, 2023	A129685
C2321878	Certificate of Analysis	Feb 15, 2023	A129685
C2321888	Certificate of Analysis	Feb 15, 2023	A129685

Solubility

Soluble in DMSO (10 mM), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and acetone.

Sensitivity

Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H360:May damage fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

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