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Anastrozole - ≥99%, high purity , Cytochrome P450 19A1 inhibitor, CAS No.120511-73-1, Cytochrome P450 19A1 inhibitor
Potent aromatase (CYP19) inhibitor
Basic Description Synonyms anastrozole|120511-73-1|Arimidex|anastrazole|Anastrozol|ZD1033|2,2'-(5-((1H-1,2,4-triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile)|Asiolex|ICI D1033|ZD-1033|ICI-D1033|HSDB 7462|ICI-D 1033|UNII-2Z07MYW1AZ|2Z07MYW1AZ|NSC-719344|NSC-759855|CCRI Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Potent and highly selective aromatase (CYP19) inhibitor (IC50= 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activityin vivo. Orally active. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Cytochrome P450 19A1 inhibitor Product Description
Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
Names and Identifiers Pubchem Sid 488179673 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488179673 IUPAC Name 2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile INCHI InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3 InChi Key YBBLVLTVTVSKRW-UHFFFAOYSA-N Canonical SMILES CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N Isomeric SMILES CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N WGK Germany 3 RTECS CZ1465000 PubChem CID 2187 Molecular Weight 293.37
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 29.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 29.34, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 , GHS07 Signal Danger Hazard Statements H301: Toxic if swallowed
H351: Suspected of causing cancer
H302: Harmful if swallowed
H360: May damage fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
WGK Germany 3 RTECS CZ1465000
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A1514054