Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC 50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
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Product Description
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC 50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation
In Vitro
Angoline (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC 50 values of 11.56, ＞100 and ＞100 μM, respectively. Angoline (0-100 μM; 2 h) affects phosphorylation of STAT3. Angoline (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HepG2/STAT3 cell line Concentration: 0, 1, 10, 30 and 100 μM Incubation Time: 2 hours Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells. Cell Proliferation AssayCell Line: MDA-MB-231, H4 and HepG2 cell lines Concentration: 0-100 μM Incubation Time: 72 hours Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC 50 values of 3.32, 4.72 and 3.14 μM, respectively.
