Anti-inflammatory agent 35 - 99%, high purity , CAS No.2293951-00-3

  • ≥99%
Item Number
A649878
Grouped product items
SKUSizeAvailabilityPrice Qty
A649878-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$80.90
A649878-10mg
10mg
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$120.90
A649878-25mg
25mg
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$250.90
A649878-50mg
50mg
Available within 8-12 weeks(?)
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$405.90
A649878-100mg
100mg
Available within 8-12 weeks(?)
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$650.90

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsAnti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo

In Vitro

Anti-inflammatory agent 35 (compound 5a27) (10 μM; 30 min) inhibits the production of proinflammatory cytokines (IL-6, TNF-α) induced by LPS (0.5 μg/mL; 24 h) without cytotoxicity in mouse primary macrophages (MPMs). Anti-inflammatory agent 35 inhibits the production of IL-6, TNF-α with IC50s of 2.23 μM and 2.40 μM, respectively. Anti-inflammatory agent 35 (10 μM; 30 min) significantly inhibits LPS-induced activation in RAW 264.7 mouse macrophages. And it markedly inhibits p-p38 and p-ERK, decreases IκB level, indicating the suppression of MAPK and NF-κB signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW 264.7 mouse macrophages Concentration: 10 μM Incubation Time: 30 min; followed by incubation with 0.5 μg/mL LPS for another 30 min Result: Decreased the phosphorylation of p38 and ERK. And down-regulated IκB (inhibitor of NF-κB), inhibits the transcription of TNF-α, IL-6, IL-1β, ICAM-1.

In Vivo

Anti-inflammatory agent 35 (compound 5a27) (50 mg/kg; po; single dose, monitored 0-25 min) has a better bioavailability than curcumin (HY-N0005) . Anti-inflammatory agent 35 (10 mg/kg; ip; once daily for 1 week) improves LPS-induced ALI by inhibiting inflammation in mice model . The pharmacokinetic parameters in rats Route Dose (mg/kg) AUC (0-t) (μg/L·h) AUC (0-∞) (μg/L·h) MRT (0-t) (h) MRT (0-∞) (h) t 1/2 (h) T max (h) CLz/F (L/h/kg) Vz/F (L/kg) C max p.o 50 231.2 325.6 7.8 12.3 6.7 3.3 5062.6 827.1 113.3 i.v 5 34.3 122.4 11.3 19.9 0.2 0.1 404.4 59.5 16.4 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: ALI mouse model (C57BL/6 mice) Dosage: 10 mg/kg Administration: Intraperitoneal injection, once daily for 1 week; 30 min later every dose, followed by 5 mg/kg LPS, intratracheal injection Result: Significantly normalized the wet/dry ratio of lungs.

Form:Solid

IC50& Target:p38 MAPK ERK I-kappaBalpha IL-6 p65 NF-κB

Names and Identifiers

Canonical SMILES CC(OC1=CC=C(/C=C/C(N2C(/C(CCC2)=C/C3=CC(OC)=C(OC)C(OC)=C3)=O)=O)C=C1OC)=O
Molecular Weight 495.52

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Chemical and Physical Properties

SolubilityDMSO : 16.67 mg/mL (33.64 mM; ultrasonic and warming and heat to 60°C)

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