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Apabetalone - 97%, high purity , CAS No.1044870-39-4, Antagonist of bromodomain containing 2;Antagonist of bromodomain containing 3;Inhibitor of bromodomain containing 3;Antagonist of bromodomain containing 4

Moligand™
≥97%

CAS#: 1044870-39-4
Formula: C₂₀H₂₂N₂O₅
Molecular Weight: 370.4
PubChem CID: 135564749
PubChem SID: 488202968

Item Number

A171804

Grouped product items
SKU	Size	Availability	Price
A171804-1mg	1mg	In stock	$14.90
A171804-5mg	5mg	In stock	$61.90
A171804-10mg	10mg	In stock	$101.90
A171804-25mg	25mg	In stock	$184.90
A171804-50mg	50mg	In stock	$328.90
A171804-100mg	100mg	In stock	$515.90
A171804-250mg	250mg	In stock	$1,161.90
A171804-1g	1g	In stock	$4,179.90

View related series

bromodomain containing 2 Antagonist bromodomain containing 3 Antagonist bromodomain containing 3 Inhibitor bromodomain containing 4 Antagonist

Basic Description

Synonyms	Apabetalone\|1044870-39-4\|RVX-208\|2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one\|RVX-000222\|RVX 208\|RVX000222\|Apabetalone [INN]\|2-[4-(2-Hydroxyethoxy)-3,5-Dimethylphenyl]-5,7-Dimethoxyquinazolin-4(3h)-One\|RVX 000222\|8R4A7GDZ1D
Specifications & Purity	97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Antagonist of bromodomain containing 2;Antagonist of bromodomain containing 3;Inhibitor of bromodomain containing 3;Antagonist of bromodomain containing 4

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 19 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRDT Tchem Bromodomain testis-specific protein 2 Activities

Discover Target: BRDT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD3 Tchem Bromodomain-containing protein 3 9 Activities

Discover Target: BRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD2 Tchem Bromodomain-containing protein 2 7 Activities

Discover Target: BRD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488202968
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488202968
IUPAC Name	2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-quinazolin-4-one
INCHI	InChI=1S/C20H22N2O5/c1-11-7-13(8-12(2)18(11)27-6-5-23)19-21-15-9-14(25-3)10-16(26-4)17(15)20(24)22-19/h7-10,23H,5-6H2,1-4H3,(H,21,22,24)
InChi Key	NETXMUIMUZJUTB-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=CC(=C1OCCO)C)C2=NC3=C(C(=CC(=C3)OC)OC)C(=O)N2
Isomeric SMILES	CC1=CC(=CC(=C1OCCO)C)C2=NC3=C(C(=CC(=C3)OC)OC)C(=O)N2
PubChem CID	135564749
Molecular Weight	370.4

PubChem CID

CAS Registry No.

Wikipedia

ChEMBL Ligand

RCSB PDB Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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17 results found

Lot Number	Certificate Type	Date	Item
E2325980	Certificate of Analysis	Apr 25, 2023	A171804
E2325997	Certificate of Analysis	Apr 25, 2023	A171804
E2325993	Certificate of Analysis	Apr 25, 2023	A171804
E2325990	Certificate of Analysis	Apr 25, 2023	A171804
E2325988	Certificate of Analysis	Apr 25, 2023	A171804
E2325987	Certificate of Analysis	Apr 25, 2023	A171804
E2325986	Certificate of Analysis	Apr 25, 2023	A171804
E2325984	Certificate of Analysis	Apr 25, 2023	A171804
E2325983	Certificate of Analysis	Apr 25, 2023	A171804
E2325979	Certificate of Analysis	Apr 25, 2023	A171804
E2325978	Certificate of Analysis	Apr 25, 2023	A171804
E2325977	Certificate of Analysis	Apr 25, 2023	A171804
E2325976	Certificate of Analysis	Apr 25, 2023	A171804
E2325974	Certificate of Analysis	Apr 25, 2023	A171804
E2325971	Certificate of Analysis	Apr 25, 2023	A171804
E2325967	Certificate of Analysis	Apr 25, 2023	A171804
D2318953	Certificate of Analysis	Nov 23, 2021	A171804

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H371:May cause damage to organs
Precautionary Statements	P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P308+P316:IF exposed or concerned: Get emergency medical help immediately.

References

1. McNeill E. (2010) RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases.. Curr Opin Investig Drugs, 11 (3): (357-64). [PMID:20178050]
2. Bailey D, Jahagirdar R, Gordon A, Hafiane A, Campbell S, Chatur S, Wagner GS, Hansen HC, Chiacchia FS, Johansson J et al.. (2010) RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.. J Am Coll Cardiol, 55 (23): (2580-9). [PMID:20513599]
3. Nicholls SJ, Gordon A, Johannson J, Ballantyne CM, Barter PJ, Brewer HB, Kastelein JJ, Wong NC, Borgman MR, Nissen SE. (2012) ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies.. Cardiovasc Drugs Ther, 26 (2): (181-7). [PMID:22349989]
4. McLure KG, Gesner EM, Tsujikawa L, Kharenko OA, Attwell S, Campeau E, Wasiak S, Stein A, White A, Fontano E et al.. (2013) RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.. PLoS ONE, 8 (12): (e83190). [PMID:24391744]
5. Jahagirdar R, Zhang H, Azhar S, Tobin J, Attwell S, Yu R, Wu J, McLure KG, Hansen HC, Wagner GS et al.. (2014) A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.. Atherosclerosis, 236 (1): (91-100). [PMID:25016363]
6. Gilham D, Smith AL, Fu L, Moore DY, Muralidharan A, Reid SPM, Stotz SC, Johansson JO, Sweeney M, Wong NCW et al.. (2021) Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.. Biomedicines, 9 (4): (437). [PMID:33919584]
7. Mills RJ, Humphrey SJ, Fortuna PRJ, Lor M, Foster SR, Quaife-Ryan GA, Johnston RL, Dumenil T, Bishop C, Rudraraju R et al.. (2021) BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.. Cell, 184 (8): (2167-2182.e22). [PMID:33811809]

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