Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
A176692-5mg | 5mg | In stock | $66.90 | |
A176692-25mg | 25mg | In stock | $232.90 | |
A176692-100mg | 100mg | In stock | $649.90 |
Restores mutant p53 activity
Synonyms | APR-246|5291-32-7|PRIMA-1MET|Eprenetapopt|2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one|2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one|APR 246|Eprenetapopt [USAN]|Z41TGB4080|3-Quinuclidinone, 2-(hydroxymethyl)-2-(methoxymethyl)- |
---|---|
Specifications & Purity | ≥97% |
Biochemical and Physiological Mechanisms | PRIMA-1Met (APR-246) is a re-activator of mutant p53 activity. It′s the methylated, more potent derivative of PRIMA-1. PRIMA-1Met covalently modifies the core domain of mutated p53 restoring the wild-type conformation and activty of p53 in tumor cells, le |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | STABILISER |
Mechanism of action | Cellular tumor antigen p53 stabiliser |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | PRIMA-1Met restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. |
ALogP | -0.1 |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
---|---|
INCHI | InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3 |
InChi Key | BGBNULCRKBVAKL-UHFFFAOYSA-N |
Canonical SMILES | COCC1(C(=O)C2CCN1CC2)CO |
Isomeric SMILES | COCC1(C(=O)C2CCN1CC2)CO |
PubChem CID | 52918385 |
Molecular Weight | 199.25 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2412009 | Certificate of Analysis | Jul 29, 2024 | A176692 |
H2412010 | Certificate of Analysis | Jul 29, 2024 | A176692 |
G2121063 | Certificate of Analysis | May 10, 2024 | A176692 |
G2121064 | Certificate of Analysis | May 10, 2024 | A176692 |
G2121142 | Certificate of Analysis | May 10, 2024 | A176692 |
Solubility | DMSO : 100 mg/mL (501.88 mM; Need ultrasonic) H2O : 50 mg/mL (250.94 mM; Need ultrasonic) |
---|
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
Starting at $69.90