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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | APR-246|5291-32-7|PRIMA-1MET|Eprenetapopt|2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one|2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one|APR 246|Eprenetapopt [USAN]|Z41TGB4080|3-Quinuclidinone, 2-(hydroxymethyl)-2-(methoxymethyl)- |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | PRIMA-1Met (APR-246) is a re-activator of mutant p53 activity. It′s the methylated, more potent derivative of PRIMA-1. PRIMA-1Met covalently modifies the core domain of mutated p53 restoring the wild-type conformation and activty of p53 in tumor cells, le |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | PRIMA-1Met restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. |
Product Properties
| ALogP | -0.1 |
|---|
Associated Targets
HDAC6 Tclin Histone deacetylase 6 0 Activities
TP53 Tchem Cellular tumor antigen p53 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Names and Identifiers
| IUPAC Name | 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
|---|---|
| INCHI | InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3 |
| InChi Key | BGBNULCRKBVAKL-UHFFFAOYSA-N |
| Canonical SMILES | COCC1(C(=O)C2CCN1CC2)CO |
| Isomeric SMILES | COCC1(C(=O)C2CCN1CC2)CO |
| PubChem CID | 52918385 |
| Molecular Weight | 199.25 |
Certificates
Certificate of Analysis(COA)
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |