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AR-C 118925XX - ≥97%(HPLC), high purity , CAS No.216657-60-2, Antagonist of P2Y 2 receptor

Moligand™
≥97%(HPLC)

CAS#: 216657-60-2
Formula: C₂₈H₂₃N₇O₃S
Molecular Weight: 537.59
PubChem CID: 54210200

Item Number

A287202

Grouped product items
SKU	Size	Availability	Price	Qty
A287202-1mg	1mg	In stock	$182.90
A287202-5mg	5mg	In stock	$365.90

Selective and competitive P2Y2antagonist

View related series

P2Y2 receptor Antagonist

Basic Description

Synonyms	5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide
Specifications & Purity	Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms	Selective, competitive P2Y2receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50= 1μM). Inhibits P2Y2receptor-induced β-arrestin transloc
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2Y 2 receptor

Associated Targets

GPR17 Tchem Uracil nucleotide/cysteinyl leukotriene receptor 0 Activities

Discover Target: GPR17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RY2 Tclin P2Y purinoceptor 2 7 Activities

Discover Target: P2RY2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[[5-(6,13-dimethyl-2-tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaenyl)-2-oxo-4-sulfanylidenepyrimidin-1-yl]methyl]-N-(2H-tetrazol-5-yl)furan-2-carboxamide
INCHI	InChI=1S/C28H23N7O3S/c1-15-3-8-20-17(11-15)5-6-18-12-16(2)4-9-21(18)24(20)22-14-35(28(37)30-26(22)39)13-19-7-10-23(38-19)25(36)29-27-31-33-34-32-27/h3-12,14,24H,13H2,1-2H3,(H,30,37,39)(H2,29,31,32,33,34,36)
InChi Key	PVKNPGQAFNALOI-UHFFFAOYSA-N
Canonical SMILES	CC1=CC2=C(C=C1)C(C3=C(C=C2)C=C(C=C3)C)C4=CN(C(=O)NC4=S)CC5=CC=C(O5)C(=O)NC6=NNN=N6
Isomeric SMILES	CC1=CC2=C(C=C1)C(C3=C(C=C2)C=C(C=C3)C)C4=CN(C(=O)NC4=S)CC5=CC=C(O5)C(=O)NC6=NNN=N6
PubChem CID	54210200
MeSH Entry Terms	5-((5-(6,13-dimethyl-2-tricyclo(9.4.0.03,8)pentadeca-1(11),3(8),4,6,9,12,14-heptaenyl)-2-oxo-4-sulfanylidenepyrimidin-1-yl)methyl)-N-(2H-tetrazol-5-yl)furan-2-carboxamide;AR-C118925XX;ARC 118925XX;ARC118925XX
Molecular Weight	537.59

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2310634	Certificate of Analysis	Jul 31, 2023	A287202
H2310646	Certificate of Analysis	Jul 31, 2023	A287202
H2310655	Certificate of Analysis	Jul 31, 2023	A287202
H2310664	Certificate of Analysis	Jul 31, 2023	A287202

Solubility

Solvent:DMSO, Max Conc. mg/mL: 53.76, Max Conc. mM: 100

Sensitivity

Light sensitive

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