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(-)-Arctigenin - ≥98%(HPLC), high purity , CAS No.7770-78-7

  • ≥98%(HPLC)
Item Number
A109807
Grouped product items
SKUSizeAvailabilityPrice Qty
A109807-50mg
50mg
In stock
$107.90
A109807-250mg
250mg
In stock
$486.90

Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation

Basic Description

SynonymsArctigenin|(-)-Arctigenin|7770-78-7|(+/-)-Arctigenin|Arctigenin, (+/-)-|UNII-U76MR9VS6M|U76MR9VS6M|Arctigenin, trans-((+/-)-|C21H24O6|(3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one|2(3H)-Furanone, 4-((3,4-dimethoxyphen
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsAntioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBαphosphorylation and p65 nuclear translocation (IC50= 10 nM). Inhibits HIV-1 replicationin vitro. Also potently inhibits MKK1
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Arctigenin is a lignan found in the root of Arctium lappa L. It has been used in pharmacologic, as well as cosmetic, research and has demonstrated several antiviral and anticancer effects.

Associated Targets

COX7A2P2 Tdark Putative cytochrome c oxidase subunit 7A3, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DAPK3 Tchem Death-associated protein kinase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK16 Tchem Cyclin-dependent kinase 16 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDKL1 Tchem Cyclin-dependent kinase-like 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PAK5 Tchem Serine/threonine-protein kinase PAK 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK17A Tchem Serine/threonine-protein kinase 17A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK26 Tchem Serine/threonine-protein kinase 26 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK10 Tchem Serine/threonine-protein kinase 10 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK16 Tchem Serine/threonine-protein kinase 16 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

STK4 Tchem Serine/threonine-protein kinase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CAMK1D Tchem Calcium/calmodulin-dependent protein kinase type 1D 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CAMK1G Tchem Calcium/calmodulin-dependent protein kinase type 1G 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TNIK Tchem TRAF2 and NCK-interacting protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLK Tchem STE20-like serine/threonine-protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIM3 Tchem Serine/threonine-protein kinase pim-3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CDK6 Tclin Cyclin-dependent kinase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein 0 Activities

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CHEK2 Tchem Serine/threonine-protein kinase Chk2 0 Activities

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CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

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CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLK2 Tchem Dual specificity protein kinase CLK2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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PAK4 Tchem Serine/threonine-protein kinase PAK 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PAK6 Tchem Serine/threonine-protein kinase PAK 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CAMK2D Tchem Calcium/calmodulin-dependent protein kinase type II subunit delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CAMK2G Tchem Calcium/calmodulin-dependent protein kinase type II subunit gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRKACA Tchem cAMP-dependent protein kinase catalytic subunit alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK3 Tchem Mitogen-activated protein kinase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RPS6KA3 Tchem Ribosomal protein S6 kinase alpha-3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDPK1 Tchem 3-phosphoinositide-dependent protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488183650
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488183650
IUPAC Name (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
INCHI InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
InChi Key NQWVSMVXKMHKTF-JKSUJKDBSA-N
Canonical SMILES COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
Isomeric SMILES COC1=C(C=C(C=C1)C[C@H]2COC(=O)[C@@H]2CC3=CC(=C(C=C3)O)OC)OC
WGK Germany 3
PubChem CID 64981
Molecular Weight 372.41

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
B2325317Certificate of AnalysisSep 19, 2022 A109807
I2209317Certificate of AnalysisSep 19, 2022 A109807
I2209318Certificate of AnalysisSep 19, 2022 A109807

Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 9.31, Max Conc. mM: 25 with gentle warming; Solvent:DMSO, Max Conc. mg/mL: 37.24, Max Conc. mM: 100
Specific Rotation[α]-42° (C=1,MeOH)
Melt Point(°C)100 °C

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

References

1. Joshua Fischer,Aaron J Reynolds,Lisa A Sharp,Michael S Sherburn.  (2004-04-23)  Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products..  Organic letters,  ((9)): (1345-1348).  [PMID:15101738]
2. Shiming Liu,Kaoshan Chen,Willibald Schliemann,Dieter Strack.  (2005-05-11)  Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS..  Phytochemical analysis : PCA,  16  ((2)): (86-89).  [PMID:15881114]
3. Suresh Awale,Jie Lu,Surya K Kalauni,Yukiko Kurashima,Yasuhiro Tezuka,Shigetoshi Kadota,Hiroyasu Esumi.  (2006-02-03)  Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation..  Cancer research,  66  ((3)): (1751-1757).  [PMID:16452235]
4. Chul Young Kim,Mi-Jeong Ahn,Jinwoong Kim.  (2006-04-12)  A preparative isolation and purification of arctigenin and matairesinol from Forsythia koreana by centrifugal partition chromatography..  Journal of separation science,  29  ((5)): (656-659).  [PMID:16605084]
5. Keiichi Ishihara,Nobuyuki Yamagishi,Youhei Saito,Midori Takasaki,Takao Konoshima,Takumi Hatayama.  (2006-07-05)  Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells..  Cell stress & chaperones,  11  ((2)): (154-161).  [PMID:16817321]
6. Wenjuan Lü,Yonglei Chen,Yuxia Zhang,Xiuping Ding,Hongli Chen,Mancang Liu.  (2007-11-09)  Microemulsion electrokinetic chromatography for the separation of arctiin and arctigenin in Fructus Arctii and its herbal preparations..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  860  ((1)): (127-133).  [PMID:17988959]
7. Hyo Sook Kang,Ji Yun Lee,Chang Jong Kim.  (2008-01-09)  Anti-inflammatory activity of arctigenin from Forsythiae Fructus..  Journal of ethnopharmacology,  116  ((2)): (305-312).  [PMID:18180122]
8. Vivek Swarup,Joydeep Ghosh,Manoj Kumar Mishra,Anirban Basu.  (2008-01-31)  Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan..  The Journal of antimicrobial chemotherapy,  61  ((3)): (679-688).  [PMID:18230688]
9. Feng Zhao,Lu Wang,Ke Liu.  (2009-05-12)  In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway..  Journal of ethnopharmacology,  122  ((3)): (457-462).  [PMID:19429312]
10. Kyoko Hayashi,Kazuto Narutaki,Yasuo Nagaoka,Toshimitsu Hayashi,Shinichi Uesato.  (2010-07-08)  Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus..  Biological & pharmaceutical bulletin,  33  ((7)): (1199-1205).  [PMID:20606313]
11. Ji Yun Lee,Chang Jong Kim.  (2010-07-08)  Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes..  Archives of pharmacal research,  33  ((6)): (947-957).  [PMID:20607501]
12. He Liu,Yupu Zhang,Yantao Sun,Xue Wang,Yujuan Zhai,Ye Sun,Shuo Sun,Aimin Yu,Hanqi Zhang,Yinghua Wang.  (2010-09-03)  Determination of the major constituents in fruit of Arctium lappa L. by matrix solid-phase dispersion extraction coupled with HPLC separation and fluorescence detection..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  878  ((28)): (2707-2711).  [PMID:20810325]
13. Xianjuan Kou,Shimei Qi,Wuxing Dai,Lan Luo,Zhimin Yin.  (2011-03-24)  Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway..  International immunopharmacology,  11  ((8)): (1095-1102).  [PMID:21426947]
14. Xiangyang Yao,Fenfen Zhu,Zhihui Zhao,Chang Liu,Lan Luo,Zhimin Yin.  (2011-05-25)  Arctigenin enhances chemosensitivity of cancer cells to cisplatin through inhibition of the STAT3 signaling pathway..  Journal of cellular biochemistry,  112  ((10)): (2837-2849).  [PMID:21608020]
15. Jin Boo Jeong,Se Chul Hong,Hyung Jin Jeong,Jin Suk Koo.  (2011-05-31)  Arctigenin induces cell cycle arrest by blocking the phosphorylation of Rb via the modulation of cell cycle regulatory proteins in human gastric cancer cells..  International immunopharmacology,  11  ((10)): (1573-1577).  [PMID:21621647]
16. Chen Gui-Rong,Cai Li-Ping,Dou De-Qiang,Kang Ting-Guo,Li Hong-Fu,Li Fu-Rui,Jiang Ning.  (2011-08-27)  Synthesis of (-)-arctigenin derivatives and their anticancer activity..  Natural product research,  26  ((2)): (177-181).  [PMID:21867457]
17. C Miele,F Beguinot.  (2012-02-24)  New expectations from the well-known medicinal properties of Arctium lappa..  Diabetologia,  55  ((5)): (1244-1246).  [PMID:22358500]
18. A-Ram Kim,Hyuk Soon Kim,Jeong Min Lee,Jung Ho Choi,Se Na Kim,Do Kyun Kim,Ji Hyung Kim,Se Hwan Mun,Jie Wan Kim,Hyun Soo Jeon,Young Mi Kim,Wahn Soo Choi.  (2012-03-06)  Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages..  European journal of pharmacology,  682  ((1-3)): (29-36).  [PMID:22387094]
19. Daquan Chen,Kaoxiang Sun,Hongjie Mu,Mingtan Tang,Rongcai Liang,Aiping Wang,Shasha Zhou,Haijun Sun,Feng Zhao,Jianwen Yao,Wanhui Liu.  (2012-06-09)  pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system..  International journal of nanomedicine,  (2621-2630).  [PMID:22679372]
20. Yuan Gu,Chunting Qi,Xiaoxiao Sun,Xiuquan Ma,Haohao Zhang,Lihong Hu,Junying Yuan,Qiang Yu.  (2012-06-13)  Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism..  Biochemical pharmacology,  84  ((4)): (468-476).  [PMID:22687625]
21. Yuan Gu,Xiao-xiao Sun,Ji-ming Ye,Li He,Shou-sheng Yan,Hao-hao Zhang,Li-hong Hu,Jun-ying Yuan,Qiang Yu.  (2012-06-19)  Arctigenin alleviates ER stress via activating AMPK..  Acta pharmacologica Sinica,  33  ((7)): (941-952).  [PMID:22705729]
22. Li-Ying Zhang,Yi-Shun Yang,Tong Zhang,Yue Ding,Zhen-Zhen Cai,Jian-Sheng Tao.  (2012-08-11)  [Research on the preparative method of Arctigenin]..  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,  35  ((3)): (467-470).  [PMID:22876688]
23. Tao Fan,Wei Long Jiang,Jian Zhu,Yu Feng Zhang.  (2012-09-14)  Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation..  Biological & pharmaceutical bulletin,  35  ((11)): (2004-2009).  [PMID:22972486]
24. Kevin Lai,Douglas W Selinger,Jonathan M Solomon,Hua Wu,Esther Schmitt,Fabrizio C Serluca,Daniel Curtis,John D Benson.  (2012-11-10)  Integrated compound profiling screens identify the mitochondrial electron transport chain as the molecular target of the natural products manassantin, sesquicillin, and arctigenin..  ACS chemical biology,  ((1)): (257-267).  [PMID:23138533]
25. Jong-Sik Jin,Jong-Hyun Lee,Masao Hattori.  (2013-01-18)  Ligand binding affinities of arctigenin and its demethylated metabolites to estrogen receptor alpha..  Molecules (Basel, Switzerland),  18  ((1)): (1122-1127).  [PMID:23325100]
26. Supriya R Hyam,In-Ah Lee,Wan Gu,Kyung-Ah Kim,Jin-Ju Jeong,Se-Eun Jang,Myung Joo Han,Dong-Hyun Kim.  (2013-02-05)  Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages..  European journal of pharmacology,  708  ((1-3)): (21-29).  [PMID:23375938]
27. Wei Wang,Qiang Pan,Xue-Ying Han,Jing Wang,Ri-Qiu Tan,Fan He,De-Qiang Dou,Ting-Guo Kang.  (2013-02-06)  Simultaneous determination of arctiin and its metabolites in rat urine and feces by HPLC..  Fitoterapia,  86  (6-12).  [PMID:23380537]
28. Xue-Ying Han,Wei Wang,Ri-Qiu Tan,De-Qiang Dou.  (2013-05-15)  [Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((3)): (432-434).  [PMID:23668024]
29. Yuan Gu,Claudia Scheuer,Dilu Feng,Michael D Menger,Matthias W Laschke.  (2013-06-08)  Inhibition of angiogenesis: a novel antitumor mechanism of the herbal compound arctigenin..  Anti-cancer drugs,  24  ((8)): (781-791).  [PMID:23744558]
30. Alexios S Strimpakos,Muhammad Wasif Saif.  (2013-07-13)  Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?.  JOP : Journal of the pancreas,  14  ((4)): (354-358).  [PMID:23846926]
31. Hongbo Li,Chunli Yang,Min Lan,Xingen Liao,Zhiming Tang.  (2019-12-29)  Arctigenin promotes bone formation involving PI3K/Akt/PPARγ signaling pathway..  Chemical biology & drug design,  95  ((4)): (451-459).  [PMID:31883507]
32. Min Kyung Cho,Young Pyo Jang,Young Choong Kim,Sang Geon Kim.  (2004-08-18)  Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition..  International immunopharmacology,  ((10-11)): (1419-1429).  [PMID:15313439]
33. Jong-Sik Jin,Yu-Feng Zhao,Norio Nakamura,Teruaki Akao,Nobuko Kakiuchi,Masao Hattori.  (2007-05-03)  Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone..  Biological & pharmaceutical bulletin,  30  ((5)): (904-911).  [PMID:17473433]
34. Takeshi Toyoda,Tetsuya Tsukamoto,Tsutomu Mizoshita,Sansei Nishibe,Takeshi Deyama,Yoshiharu Takenaka,Naoki Hirano,Harunari Tanaka,Shinji Takasu,Hisayo Ban,Toshiko Kumagai,Ken-Ichi Inada,Hirotoshi Utsunomiya,Masae Tatematsu.  (2007-09-27)  Inhibitory effect of nordihydroguaiaretic acid, a plant lignan, on Helicobacter pylori-associated gastric carcinogenesis in Mongolian gerbils..  Cancer science,  98  ((11)): (1689-1695).  [PMID:17894552]
35. Giovanni Dinelli,Ilaria Marotti,Sara Bosi,Stefano Benedettelli,Lisetta Ghiselli,Sonia Cortacero-Ramírez,Alegría Carrasco-Pancorbo,Antonio Segura-Carretero,Alberto Fernández-Gutiérrez.  (2007-10-20)  Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses..  Electrophoresis,  28  ((22)): (4212-4219).  [PMID:17948259]
36. Ju-Young Kim,Ji-Hwan Hwang,Mi-Ran Cha,Mi-Young Yoon,Eun-Soon Son,Akihiro Tomida,Bosung Ko,Si-Whan Song,Kazuo Shin-ya,Yong-il Hwang,Hae-Ryong Park.  (2010-03-17)  Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity..  Journal of cellular physiology,  224  ((1)): (33-40).  [PMID:20232300]
37. Kyungsu Kang,Hee Ju Lee,Ji-Hye Yoo,Eun Hye Jho,Chul Young Kim,Minkyun Kim,Chu Won Nho.  (2011-06-15)  Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry..  DNA and cell biology,  30  ((8)): (623-629).  [PMID:21663531]
38. Xuan Tang,Jingjing Zhuang,Jing Chen,Liang Yu,Lihong Hu,Hualiang Jiang,Xu Shen.  (2011-09-03)  Arctigenin efficiently enhanced sedentary mice treadmill endurance..  PloS one,  ((8)): (e24224-e24224).  [PMID:21887385]
39. S-L Huang,R-T Yu,J Gong,Y Feng,Y-L Dai,F Hu,Y-H Hu,Y-D Tao,Y Leng.  (2011-11-19)  Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice..  Diabetologia,  55  ((5)): (1469-1481).  [PMID:22095235]
40. Fan He,De-Qiang Dou,Qiang Hou,Yu Sun,Ting-Guo Kang.  (2012-03-13)  Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method..  Natural product research,  27  ((10)): (903-906).  [PMID:22404522]
41. Xiangyang Yao,Guilan Li,Chaotian Lü,Hui Xu,Zhimin Yin.  (2012-07-10)  Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity..  International immunopharmacology,  14  ((2)): (138-144).  [PMID:22770942]
42. Carmen Formisano,Daniela Rigano,Alessandra Russo,Venera Cardile,Silvia Caggia,Nelly Apostolides Arnold,Angela Mari,Sonia Piacente,Sergio Rosselli,Felice Senatore,Maurizio Bruno.  (2012-09-12)  Phytochemical profile and apoptotic activity of Onopordum cynarocephalum..  Planta medica,  78  ((15)): (1651-1660).  [PMID:22965548]
43. Naoki Kudou,Akira Taniguchi,Kenji Sugimoto,Yuji Matsuya,Masashi Kawasaki,Naoki Toyooka,Chika Miyoshi,Suresh Awale,Dya Fita Dibwe,Hiroyasu Esumi,Shigetoshi Kadota,Yasuhiro Tezuka.  (2013-01-05)  Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy..  European journal of medicinal chemistry,  60  (76-88).  [PMID:23287053]
44. Qiong Gao,Yufeng Zhang,Siukwan Wo,Zhong Zuo.  (2013-03-23)  Hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by LC/MS/MS after oral administration in rats..  Planta medica,  79  ((6)): (471-479).  [PMID:23519790]
45. Quanfei Zou,Yuan Gu,Rong Lu,Tiejun Zhang,Guang-Rong Zhao,Changxiao Liu,Duanyun Si.  (2013-05-04)  Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study..  Biomedical chromatography : BMC,  27  ((9)): (1123-1128).  [PMID:23640910]
46. Simmy Thomas,Natasha Sharma,Reyna Gonzalez,Peng-Wen Pao,Florence M Hofman,Thomas C Chen,Stan G Louie,Michael C Pirrung,Axel H Schönthal.  (2013-06-12)  Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I..  PloS one,  ((6)): (e65695-e65695).  [PMID:23755268]
47. Nan Zhang,Qingping Wen,Lu Ren,Wenbo Liang,Yang Xia,Xiaodan Zhang,Dan Zhao,Dong Sun,Yv Hu,Haiguang Hao,Yaping Yan,Guangxian Zhang,Jingxian Yang,Tingguo Kang.  (2013-09-13)  Neuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells..  International journal of molecular sciences,  14  ((9)): (18657-18669).  [PMID:24025424]
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