| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A655936-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $367.90 |
Terpenoids Sesquiterpenes
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability. In Vitro Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage . MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Canonical SMILES | CC1CCC2C(=C)C(=O)OC3C24C1CCC(O3)(OO4)C |
|---|---|
| Molecular Weight | 280.32 |
Enter Lot Number to search for COA:
