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AS 1842856 - ≥98%(HPLC), high purity , CAS No.836620-48-5
Potent and selective Foxo1 inhibitor
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective Foxo1 inhibitor (IC50values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis bothin vitroandin vivo. Att Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488202310 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202310 IUPAC Name 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid INCHI InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25) InChi Key MOMCHYGXXYBDCD-UHFFFAOYSA-N Canonical SMILES CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O Isomeric SMILES CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O PubChem CID 72193864 Molecular Weight 347.39
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 1.74, Max Conc. mM: 5 with gentle warming
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A2306401