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Asapiprant - 98%, high purity , CAS No.932372-01-5, Antagonist of DP 1 receptor

Moligand™
≥98%

CAS#: 932372-01-5
Formula: C₂₄H₂₇N₃O₇S
Molecular Weight: 501.55
PubChem CID: 59232326

Item Number

A412177

Grouped product items
SKU	Size	Availability	Price
A412177-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
A412177-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
A412177-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$503.90
A412177-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$814.90
A412177-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,120.90

View related series

DP1 receptor Antagonist

Basic Description

Synonyms	Asapiprant\|932372-01-5\|Asapiprant [INN]\|BGE-175\|BGE175\|B2LW71CRGL\|S-555739\|2-(5-(4-((4-isopropoxyphenyl)sulfonyl)piperazin-1-yl)-2-(oxazol-2-yl)phenoxy)acetic acid\|2-(2-(Oxazol-2-yl)-5-(4-(4-((propan-2-yl)oxy)benzenesulfonyl(piperazin-1-yl)phenoxy)acetic
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of DP 1 receptor
Product Description	Information Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.

Associated Targets

PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype 0 Activities

Discover Target: PTGER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 0 Activities

Discover Target: PTGER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER1 Tclin Prostaglandin E2 receptor EP1 subtype 0 Activities

Discover Target: PTGER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGFR Tclin Prostaglandin F2-alpha receptor 0 Activities

Discover Target: PTGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER3 Tclin Prostaglandin E2 receptor EP3 subtype 0 Activities

Discover Target: PTGER3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TBXA2R Tclin Thromboxane A2 receptor 0 Activities

Discover Target: TBXA2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[2-(1,3-oxazol-2-yl)-5-[4-(4-propan-2-yloxyphenyl)sulfonylpiperazin-1-yl]phenoxy]acetic acid
INCHI	InChI=1S/C24H27N3O7S/c1-17(2)34-19-4-6-20(7-5-19)35(30,31)27-12-10-26(11-13-27)18-3-8-21(24-25-9-14-32-24)22(15-18)33-16-23(28)29/h3-9,14-15,17H,10-13,16H2,1-2H3,(H,28,29)
InChi Key	ZMZNWNTZRWXTJU-UHFFFAOYSA-N
Canonical SMILES	CC(C)OC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=CC(=C(C=C3)C4=NC=CO4)OCC(=O)O
Isomeric SMILES	CC(C)OC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=CC(=C(C=C3)C4=NC=CO4)OCC(=O)O
Alternate CAS	932372-01-5
PubChem CID	59232326
MeSH Entry Terms	2-(2-(oxazol-2-yl)-5-(4-(4-((propan-2-yl)oxy)benzenesulfonyl(piperazin-1-yl)phenoxy)acetic acid;asapiprant;BGE 175;BGE-175;S-555739
Molecular Weight	501.55

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
B2426437	Certificate of Analysis	Jan 17, 2024	A412177
B2426438	Certificate of Analysis	Jan 17, 2024	A412177
B2426439	Certificate of Analysis	Jan 17, 2024	A412177
B2426440	Certificate of Analysis	Jan 17, 2024	A412177
B2426441	Certificate of Analysis	Jan 17, 2024	A412177
B2426442	Certificate of Analysis	Jan 17, 2024	A412177
B2426443	Certificate of Analysis	Jan 17, 2024	A412177
B2426444	Certificate of Analysis	Jan 17, 2024	A412177
B2426445	Certificate of Analysis	Jan 17, 2024	A412177
B2426446	Certificate of Analysis	Jan 17, 2024	A412177

References

1. Takahashi G, Asanuma F, Suzuki N, Hattori M, Sakamoto S, Kugimiya A, Tomita Y, Kuwajima G, Abraham WM, Deguchi M et al.. (2015) Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma.. Eur J Pharmacol, 765 (3): (15-23). [PMID:26277322]
2. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P et al.. (2022) Eicosanoid signaling blockade protects middle-aged mice from severe COVID-19.. Nature, 129 (3): (589-97). [PMID:35314834]

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