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ASK1-IN-1 - 98%, high purity , CAS No.2411382-24-4

≥98%

CAS#: 2411382-24-4
Formula: C₁₉H₁₉N₉O₂
Molecular Weight: 405.41
PubChem CID: 146027049

Item Number

A412921

Grouped product items
SKU	Size	Availability	Price
A412921-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
A412921-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$219.90
A412921-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$369.90
A412921-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$649.90

View related series

Inhibitors&Agonists MAPK/ERK Pathway p38 MAPK

Basic Description

Synonyms	N-(6-(4-Isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-methoxy-1-(pyrazin-2-yl)-1H-pyrazole-4-carboxamide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	ASK1-IN-1 is a CNS-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 138 nM and 21 nM in cell-based assay and biochemical assay, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 1 Activities

Discover Target: MAP3K5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	3-methoxy-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1-pyrazin-2-ylpyrazole-4-carboxamide
INCHI	InChI=1S/C19H19N9O2/c1-12(2)27-11-22-25-17(27)14-5-4-6-15(23-14)24-18(29)13-10-28(26-19(13)30-3)16-9-20-7-8-21-16/h4-12H,1-3H3,(H,23,24,29)
InChi Key	FTPVMITWJIXRGQ-UHFFFAOYSA-N
Canonical SMILES	CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CN(N=C3OC)C4=NC=CN=C4
Isomeric SMILES	CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CN(N=C3OC)C4=NC=CN=C4
PubChem CID	146027049
Molecular Weight	405.41

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8 results found

Lot Number	Certificate Type	Date	Item
B2428432	Certificate of Analysis	Jan 22, 2024	A412921
B2428445	Certificate of Analysis	Jan 22, 2024	A412921
B2428447	Certificate of Analysis	Jan 22, 2024	A412921
B2428449	Certificate of Analysis	Jan 22, 2024	A412921
B2428451	Certificate of Analysis	Jan 22, 2024	A412921
B2428455	Certificate of Analysis	Jan 22, 2024	A412921
B2428456	Certificate of Analysis	Jan 22, 2024	A412921
B2428458	Certificate of Analysis	Jan 22, 2024	A412921

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