Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases
In Vitro
Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC 50 of 12 μM and 49 μM, respectiveiy. MCE has not independently confirmed the accuracy of these methods. They are for reference only.