AZ 11645373 - ≥98%(HPLC), high purity , CAS No.227088-94-0, Allosteric modulator of P2X7

Item Number

A287886

Grouped product items
SKU	Size	Availability	Price
A287886-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$33.90
A287886-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$129.90
A287886-10mg	10mg	In stock	$332.90
A287886-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$448.90
A287886-50mg	50mg	In stock	$1,199.90
A287886-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,472.90

Potent and selective human P2X7antagonist

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Basic Description

Synonyms	227088-94-0\|AZ-11645373\|3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE\|AZ 11645373\|AZ11645373\|XY4SZP4C72\|2,4-Thiazolidinedione, 3-(1-(((3'-nitro(1,1'-biphenyl)-4-yl)oxy)methyl)-3-(4-pyridinyl)propyl)-\|UNII-XY
Specifications & Purity	≥98%(HPLC)
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of P2X7
Product Description	Human P2X7 antagonist,potent and selective

Names and Identifiers

IUPAC Name	3-[1-[4-(3-nitrophenyl)phenoxy]-4-pyridin-4-ylbutan-2-yl]-1,3-thiazolidine-2,4-dione
INCHI	InChI=1S/C24H21N3O5S/c28-23-16-33-24(29)26(23)21(7-4-17-10-12-25-13-11-17)15-32-22-8-5-18(6-9-22)19-2-1-3-20(14-19)27(30)31/h1-3,5-6,8-14,21H,4,7,15-16H2
InChi Key	VQEHBLGYANQWEA-UHFFFAOYSA-N
Canonical SMILES	C1C(=O)N(C(=O)S1)C(CCC2=CC=NC=C2)COC3=CC=C(C=C3)C4=CC(=CC=C4)[N+](=O)[O-]
Isomeric SMILES	C1C(=O)N(C(=O)S1)C(CCC2=CC=NC=C2)COC3=CC=C(C=C3)C4=CC(=CC=C4)[N+](=O)[O-]
PubChem CID	9804433
Molecular Weight	463.51

CAS Registry No.

PubChem CID

ChEMBL Ligand

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
K2328387	Certificate of Analysis	Nov 09, 2023	A287886
K2328388	Certificate of Analysis	Nov 09, 2023	A287886
K2328389	Certificate of Analysis	Nov 09, 2023	A287886
K2328390	Certificate of Analysis	Nov 09, 2023	A287886
K2328400	Certificate of Analysis	Nov 09, 2023	A287886
K2328401	Certificate of Analysis	Nov 09, 2023	A287886
K2328402	Certificate of Analysis	Nov 09, 2023	A287886
K2328458	Certificate of Analysis	Nov 09, 2023	A287886

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H335:May cause respiratory irritation H318:Causes serious eye damage
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Basic Description