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AZ8838 - 98%, high purity , CAS No.2100285-41-2, Antagonist of PAR2

  • Moligand™
  • ≥98%
Item Number
A607846
Grouped product items
SKUSizeAvailabilityPrice Qty
A607846-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$159.90
A607846-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90
A607846-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90
A607846-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$999.90

Basic Description

Specifications & Purity98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of PAR2
Product Description

AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2.

Associated Targets

F2RL1 Tchem Proteinase-activated receptor 2 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (R)-(4-fluoro-2-propylphenyl)-(1H-imidazol-2-yl)methanol
INCHI InChI=1S/C13H15FN2O/c1-2-3-9-8-10(14)4-5-11(9)12(17)13-15-6-7-16-13/h4-8,12,17H,2-3H2,1H3,(H,15,16)/t12-/m1/s1
InChi Key IDFPQEHZYBXIFO-GFCCVEGCSA-N
Canonical SMILES CCCC1=C(C=CC(=C1)F)C(C2=NC=CN2)O
PubChem CID 132117107
Molecular Weight 234.27

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO:200 mg/mL(853.72mM;Need ultrasonic)

Related Documents

References

1. Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS et al..  (2017)  Structural insight into allosteric modulation of protease-activated receptor 2..  Nature,  545  (7652): (112-115).  [PMID:28445455]

Solution Calculators