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AZD0328 , Neuronal acetylcholine receptor protein alpha-7 subunit agonist, CAS No.220099-91-2, Neuronal acetylcholine receptor protein alpha-7 subunit agonist

  • Moligand™
Item Number
A607853
Grouped product items
SKUSizeAvailabilityPrice Qty
A607853-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
A607853-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
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View related series
5-HT3A Antagonist nicotinic acetylcholine receptor α7 subunit Agonist

Basic Description

Synonyms220099-91-2|AZD-0328|AZD0328|AZD 0328|(2R)-3H-1'-Azaspiro[furo[2,3-b]pyridine-2,3'-bicyclo[2.2.2]octane]|Spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine], (2'R)-|2B218X5QIY|CHEMBL2151437|AR-R23465XX|(3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-
Specifications & PurityMoligand™
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionNeuronal acetylcholine receptor protein alpha-7 subunit agonist

Product Properties

ALogP1.6

Associated Targets

CHRNA7 Tchem Neuronal acetylcholine receptor subunit alpha-7 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CHRNB2 Tclin Neuronal acetylcholine receptor subunit beta-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HTR3A Tclin 5-hydroxytryptamine receptor 3A 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]
INCHI InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1
InChi Key OCKIPDMKGPYYJS-ZDUSSCGKSA-N
Canonical SMILES C1CN2CCC1C3(C2)CC4=C(O3)N=CC=C4
Isomeric SMILES C1CN2CCC1[C@@]3(C2)CC4=C(O3)N=CC=C4
PubChem CID 9794392
Molecular Weight 216.28

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP et al..  (2009)  Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes..  Biochem Pharmacol,  78  (7): (880-8).  [PMID:19615981]

Solution Calculators

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