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AZD1080 - ≥98%, high purity , CAS No.612487-72-6, Inhibitor of glycogen synthase kinase 3 alpha;Inhibitor of glycogen synthase kinase 3 beta

≥98%

CAS#: 612487-72-6
Formula: C₁₉H₁₈N₄O₂
Molecular Weight: 334.37
PubChem CID: 135564570

Item Number

A126905

Grouped product items
SKU	Size	Availability	Price	Qty
A126905-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$97.90
A126905-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$441.90

View related series

glycogen synthase kinase 3 alpha Inhibitor glycogen synthase kinase 3 beta Inhibitor

Basic Description

Synonyms	AZD1080\|612487-72-6\|AZD-1080\|2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile\|AZ-11548415\|0TII45R8IJ\|AZD 1080\|UNII-0TII45R8IJ\|2-Hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile\|2-Hydroxy-3-[5-(4-morpholiny
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Inhibitor of glycogen synthase kinase 3 alpha;Inhibitor of glycogen synthase kinase 3 beta
Product Description	AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

Associated Targets

GSK3B Tclin Glycogen synthase kinase-3 beta 1 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3A Tclin Glycogen synthase kinase-3 alpha 1 Activities

Discover Target: GSK3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile
INCHI	InChI=1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChi Key	BLTVBQXJFVRPFK-UHFFFAOYSA-N
Canonical SMILES	C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O
Isomeric SMILES	C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O
PubChem CID	135564570
Molecular Weight	334.37

PubChem CID

CAS Registry No.

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2 results found

Lot Number	Certificate Type	Date	Item
D1615040	Certificate of Analysis	Sep 07, 2023	A126905
A1822001	Certificate of Analysis	Jun 08, 2023	A126905

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