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Transmembrane Transporters
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Transient Receptor Potential channels (TRP)
AZD1386 , Vanilloid receptor antagonist, CAS No.946080-23-5, Vanilloid receptor antagonist

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AZD1386 , Vanilloid receptor antagonist, CAS No.946080-23-5, Vanilloid receptor antagonist

Moligand™

CAS#: 946080-23-5
Formula: C₁₉H₁₃ClF₃N₃O₃
Molecular Weight: 423.8
PubChem CID: 24752296

Item Number

A607856

Grouped product items
SKU	Size	Availability	Price	Qty
A607856-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607856-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90

View related series

TRPV1 Inhibitor

Basic Description

Synonyms	azd1386\|AZD 1386\|946080-23-5\|CID 24752296\|5'-chloro-7'-methyl-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione\|5/'-chloro-7/'-methyl-1/'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3/'-indole]-2,2/',4-trion
Grade	Moligand™
Action Type	ANTAGONIST, INHIBITOR
Mechanism of action	Vanilloid receptor antagonist

Product Properties

ALogP	3.2

Associated Targets

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 1 Activities

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5'-chloro-7'-methyl-1'-[[3-(trifluoromethyl)phenyl]methyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione
INCHI	InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)
InChi Key	DXDVSYALLVVBOV-UHFFFAOYSA-N
Canonical SMILES	O=C1NC(=O)C2(N1)c1cc(Cl)cc(c1N(C2=O)Cc1cccc(c1)C(F)(F)F)C
Isomeric SMILES	CC1=CC(=CC2=C1N(C(=O)C23C(=O)NC(=O)N3)CC4=CC(=CC=C4)C(F)(F)F)Cl
PubChem CID	24752296
Molecular Weight	423.8

Database links

PubChem CID	24752296
CAS Registry No.	946080-23-5

Certificates

Certificate of Analysis(COA)

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References

1. Quiding H, Jonzon B, Svensson O, Webster L, Reimfelt A, Karin A, Karlsten R, Segerdahl M. (2013) TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction.. Pain, 154 (6): (808-12). [PMID:23541425]

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