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AZD3778 , CAS No.1032129-23-9, Antagonist of CCR3;Antagonist of H 1 receptor;Channel blocker of K v11.1

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AZD3778 , CAS No.1032129-23-9, Antagonist of CCR3;Antagonist of H 1 receptor;Channel blocker of K v11.1

Moligand™

CAS#: 1032129-23-9
PubChem CID: 11753159

Item Number

A607865

Grouped product items
SKU	Size	Availability	Price	Qty
A607865-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A607865-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

CCR3 Antagonist H1 receptor Antagonist Kv11.1 Channel blocker

Basic Description

Synonyms	AZD3778\|AZD-3778\|9BC2MUG4A8\|UNII-9BC2MUG4A8\|CHEMBL2158814\|AZD-3778 [WHO-DD]\|485391-80-8\|(1,4'-Bipiperidine)-1'-carboxamide, 4-(3,4-dichlorophenoxy)-N-((4-methylphenyl)sulfonyl)-\|4-(3,4-Dichlorophenoxy)-N-((4-methylphenyl)sulfonyl)(1,4'-bipiperidine)-1'-ca
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER
Mechanism of action	Antagonist of CCR3;Antagonist of H 1 receptor;Channel blocker of K v11.1

Associated Targets

CCR3 Tchem C-C chemokine receptor type 3 5 Activities

Discover Target: CCR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH1 Tclin Histamine H1 receptor 4 Activities

Discover Target: HRH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 1 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-N-(4-methylphenyl)sulfonylpiperidine-1-carboxamide
INCHI	InChI=1S/C24H29Cl2N3O4S/c1-17-2-5-21(6-3-17)34(31,32)27-24(30)29-12-8-18(9-13-29)28-14-10-19(11-15-28)33-20-4-7-22(25)23(26)16-20/h2-7,16,18-19H,8-15H2,1H3,(H,27,30)
InChi Key	QVLZVRFIGXNZMN-UHFFFAOYSA-N
Canonical SMILES	Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl
Isomeric SMILES	CC1=CC=C(C=C1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)OC4=CC(=C(C=C4)Cl)Cl
PubChem CID	11753159

Database links

PubChem CID	11753159
ChEMBL Ligand	CHEMBL2158814
CAS Registry No.	1032129-23-9
GPCRdb Ligand	AZD3778

Certificates

Certificate of Analysis(COA)

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References

1. Cook D, Brown D, Alexander R, March R, Morgan P, Satterthwaite G, Pangalos MN. (2014) Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.. Nat Rev Drug Discov, 13 (6): (419-31). [PMID:24833294]

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