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AZD5904 , CAS No.A607876, Inhibitor of myeloperoxidase

  • Moligand™
  • ≥98%
Item Number
A607876
Grouped product items
SKUSizeAvailabilityPrice Qty
A607876-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
A607876-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$149.90
A607876-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
A607876-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$549.90
A607876-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$771.90
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Drug targets Glutathione Peroxidase Inhibitors&Agonists Metabolize myeloperoxidase Inhibitor

Basic Description

Synonyms2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1,2,3,7-tetrahydro-6H-purin-6-one | AZD 5904 [WHO-DD] | 3-[[(2~{R})-oxolan-2-yl]methyl]-2-sulfanylidene-9~{H}-purin-6-one | 62A9CG81VN | Q27074766 | MS-23562 | 1,2,3,9-Tetrahydro-3-(((2R)-tetrahydro-2-fu
Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of myeloperoxidase
Product Description

AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

Associated Targets

TPO Tclin Thyroid peroxidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MPO Tchem Myeloperoxidase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[[(2R)-oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one
INCHI InChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m1/s1
InChi Key RSPDBEVKURKEII-ZCFIWIBFSA-N
Canonical SMILES C1CC(OC1)CN2C3=C(C(=O)NC2=S)NC=N3
Isomeric SMILES C1C[C@@H](OC1)CN2C3=C(C(=O)NC2=S)NC=N3
Alternate CAS 618913-30-7
PubChem CID 10264211
Molecular Weight 252.29

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO: 2 mg/mL, clear

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Warning
Hazard Statements

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P405:Store locked up.

P501:Dispose of contents/container to ...

P203:Obtain, read and follow all safety instructions before use.

P318:if exposed or concerned, get medical advice.

Related Documents

 SDS

 Specification Sheet

References

1. Tidén AK, Sjögren T, Svensson M, Bernlind A, Senthilmohan R, Auchère F, Norman H, Markgren PO, Gustavsson S, Schmidt S et al..  (2011)  2-thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation..  J Biol Chem,  286  (43): (37578-89).  [PMID:21880720]

Solution Calculators

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