Azenosertib (Zn-C3) - 98%, high purity , CAS No.2376146-48-2, Inhibitor of WEE1 G2 checkpoint kinase

Item Number

A607901

Grouped product items
SKU	Size	Availability	Price
A607901-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
A607901-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
A607901-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$563.90
A607901-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$933.90

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Basic Description

Synonyms	compound 16 [PMID: 34423975] \| azenosertib \| Azenosertib [INN] \| EX-A6113 \| 9J13XU96Z1 \| (R)-2-allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one \|
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of WEE1 G2 checkpoint kinase
Product Description	ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.

Names and Identifiers

IUPAC Name	1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
INCHI	InChI=1S/C29H34N8O2/c1-4-14-36-27(38)23-19-30-28(31-21-7-9-22(10-8-21)35-17-15-34(3)16-18-35)33-26(23)37(36)24-11-6-20-12-13-29(39,5-2)25(20)32-24/h4,6-11,19,39H,1,5,12-18H2,2-3H3,(H,30,31,33)/t29-/m1/s1
InChi Key	OXTSYWDBUVRXFF-GDLZYMKVSA-N
Canonical SMILES	O=c1n(CC=C)n(c2ccc3CC[C@@](CC)(O)c3n2)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc12
Isomeric SMILES	CC[C@]1(CCC2=C1N=C(C=C2)N3C4=NC(=NC=C4C(=O)N3CC=C)NC5=CC=C(C=C5)N6CCN(CC6)C)O
PubChem CID	139467635
Molecular Weight	526.63

PubChem CID

RCSB PDB Ligand

CAS Registry No.

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8 results found

Lot Number	Certificate Type	Date	Item
C2414166	Certificate of Analysis	Jan 29, 2024	A607901
C2414167	Certificate of Analysis	Jan 29, 2024	A607901
C2414168	Certificate of Analysis	Jan 29, 2024	A607901
C2414169	Certificate of Analysis	Jan 29, 2024	A607901
C2414170	Certificate of Analysis	Jan 29, 2024	A607901
C2414171	Certificate of Analysis	Jan 29, 2024	A607901
C2414172	Certificate of Analysis	Jan 29, 2024	A607901
C2414173	Certificate of Analysis	Jan 29, 2024	A607901

References

1. Huang PQ, Boren BC, Hegde SG, Liu H, Unni AK, Abraham S, Hopkins CD, Paliwal S, Samatar AA, Li J et al.. (2021) Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.. J Med Chem, 64 (17): (13004-13024). [PMID:34423975]

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Basic Description