This heterobifunctional, PEGylated crosslinker 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG6-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC®molecules) fortargeted protein degradation.
1.Yong Ma, Hailong Zhang, Xue-Long Sun,. (2010-10-14) Surface-bound cytomimetic assembly based on chemoselective and biocompatible immobilization and further modification of intact liposome.. Bioconjugate chemistry, 21 ((11)):( 1994-1999 ). [PMID:20939526]
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