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Home Bioactive Small Molecules Azilsartan - ≥98% (HPLC), high purity , Type-1 angiotensin II receptor antagonist, CAS No.147403-03-0, Type-1 angiotensin II receptor antagonist
Azilsartan - ≥98% (HPLC), high purity , Type-1 angiotensin II receptor antagonist, CAS No.147403-03-0, Type-1 angiotensin II receptor antagonist
Potent AT1inverse agonist; antihypertensive
Basic Description Synonyms Azilsartan|147403-03-0|TAK-536|TAK 536|UNII-F9NUX55P23|F9NUX55P23|TAK536|CHEBI:68850|HSDB 8208|Azilsartan (TAK-536)|CHEMBL57242|DTXSID70163712|1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]- Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent angiotensin II type 1 (AT1) receptor inverse agonist (IC50= 2.6 nM at the human AT1receptor). Inhibits angiotensin II-induced IP1 accumulation in COS-7 cells; decreases maximal contraction of rabbit aortic strips in a concentration-dependent manner Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Type-1 angiotensin II receptor antagonist Note 50mg、250mg、10mg卖完停产，不再备货
Names and Identifiers Pubchem Sid 488202872 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202872 IUPAC Name 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid INCHI InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32) InChi Key KGSXMPPBFPAXLY-UHFFFAOYSA-N Canonical SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O Isomeric SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O WGK Germany 3 PubChem CID 135415867 Molecular Weight 456.45
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 45.65, Max Conc. mM: 100 Sensitivity Heat Sensitive Melt Point(°C) 188 °C(dec.)
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
WGK Germany 3
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