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Azilsartan - ≥99%, high purity , CAS No.147403-03-0, Antagonist of AT 1 receptor
Basic Description Synonyms Azilsartan|147403-03-0|TAK-536|TAK 536|UNII-F9NUX55P23|F9NUX55P23|TAK536|CHEBI:68850|HSDB 8208|Azilsartan (TAK-536)|CHEMBL57242|DTXSID70163712|1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]- Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Azilsartan is a highly potent and slowly dissociating Angiotensin II type 1 (AT1) receptor blocker (ARB) with an IC50 of 2.6 nM. It is the active form of Azilsartan medoxomil, used for treatment of hypertension. Azilsartan may also have potentially benefi Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of AT 1 receptor Note 10mg、50mg卖完停产，不再备货
Names and Identifiers IUPAC Name 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid INCHI InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32) InChi Key KGSXMPPBFPAXLY-UHFFFAOYSA-N Canonical SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O Isomeric SMILES CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O WGK Germany 3 PubChem CID 135415867 Molecular Weight 456.45
Chemical and Physical Properties Solubility DMSO: soluble15 mg/mL Sensitivity Heat sensitive Melt Point(°C) 188 °C(dec.)
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H372: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H361: Suspected of damaging fertility or the unborn child
H362: May cause harm to breast-fed children
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P263: Avoid contact during pregnancy/while nursing.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
WGK Germany 3
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