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B I09 - ≥98%(HPLC), high purity , CAS No.1607803-67-7

Item Number

B287381

Grouped product items
SKU	Size	Availability	Price	Qty
B287381-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90
B287381-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$741.90

IRE1 endonuclease inhibitor; cell permeable

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Basic Description

Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	IRE-1 RNase inhibitor (IC50= 1.23μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cellsin vitroand promotes CLL regression in a mouse model.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one
INCHI	InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2
InChi Key	UYYMWNUDIOPESF-UHFFFAOYSA-N
Canonical SMILES	C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O
Isomeric SMILES	C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O
PubChem CID	86290458
Molecular Weight	303.31

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Solubility	Solvent:DMSO, Max Conc. mg/mL: 15.17, Max Conc. mM: 50

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