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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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B287381-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $197.90 | |
B287381-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $741.90 |
IRE1 endonuclease inhibitor; cell permeable
Synonyms | 7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | IRE-1 RNase inhibitor (IC50= 1.23μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cellsin vitroand promotes CLL regression in a mouse model. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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IUPAC Name | 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one |
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INCHI | InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2 |
InChi Key | UYYMWNUDIOPESF-UHFFFAOYSA-N |
Canonical SMILES | C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O |
Isomeric SMILES | C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O |
PubChem CID | 86290458 |
Molecular Weight | 303.31 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 15.17, Max Conc. mM: 50 |
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