B I09 - ≥98%(HPLC), high purity , CAS No.1607803-67-7

  • ≥98%(HPLC)
Item Number
B287381
Grouped product items
SKUSizeAvailabilityPrice Qty
B287381-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$197.90
B287381-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$741.90

IRE1 endonuclease inhibitor; cell permeable

Basic Description

Synonyms7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsIRE-1 RNase inhibitor (IC50= 1.23μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cellsin vitroand promotes CLL regression in a mouse model.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

Serine/threonine-protein kinase/endoribonuclease IRE1 1682 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Names and Identifiers

IUPAC Name 7-(1,3-dioxan-2-yl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one
INCHI InChI=1S/C16H17NO5/c18-12-3-2-10-9-4-5-17-8-11(9)15(19)22-14(10)13(12)16-20-6-1-7-21-16/h2-3,16-18H,1,4-8H2
InChi Key UYYMWNUDIOPESF-UHFFFAOYSA-N
Canonical SMILES C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O
Isomeric SMILES C1COC(OC1)C2=C(C=CC3=C2OC(=O)C4=C3CCNC4)O
PubChem CID 86290458
Molecular Weight 303.31

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 15.17, Max Conc. mM: 50

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Solution Calculators