BACE1-IN-1 - 99%, high purity , CAS No.1310347-50-2

Item Number

B651463

Grouped product items
SKU	Size	Availability	Price
B651463-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$200.90
B651463-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$500.90
B651463-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90

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Basic Description

Synonyms	BACE1-IN-1\|1310347-50-2\|B67UFT75QS\|RG7129\|N-[3-[(4r)-2-Azanylidene-5,5-Bis(Fluoranyl)-4-Methyl-1,3-Oxazinan-4-Yl]-4-Fluoranyl-Phenyl]-5-Cyano-Pyridine-2-Carboxamide\|UNII-B67UFT75QS\|CHEMBL2347215\|RO-5508887\|2-Pyridinecarboxamide, N-(3-((4R)-2-amino-5,5-dif
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC 50 s of 32 and 47 nM for human BACE1 and BACE2 , respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC 50 s of 32 and 47 nM for human BACE1 and BACE2 , respectively. Form:Solid IC50& Target:IC50: 32 nM (human BACE1), 47 nM (human BACE2)

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[3-[(4R)-2-amino-5,5-difluoro-4-methyl-6H-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
INCHI	InChI=1S/C18H14F3N5O2/c1-17(18(20,21)9-28-16(23)26-17)12-6-11(3-4-13(12)19)25-15(27)14-5-2-10(7-22)8-24-14/h2-6,8H,9H2,1H3,(H2,23,26)(H,25,27)/t17-/m1/s1
InChi Key	DVMUZHLUMHPCGZ-QGZVFWFLSA-N
Canonical SMILES	CC1(C(COC(=N1)N)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
Isomeric SMILES	C[C@]1(C(COC(=N1)N)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
Alternate CAS	1310347-50-2
PubChem CID	53241828
Molecular Weight	389.33

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Basic Description