Bardoxolone Methyl - ≥98%, high purity , CAS No.218600-53-4, Antagonist of Peroxisome proliferator-activated receptor-γ

Item Number

B129704

• Synonyms: Bardoxolone methyl | 218600-53-4 | CDDO-Me | CDDO methyl ester | RTA 402 | NSC 713200 | CDDO-Methyl ester | RTA-402 | RTA402 | NSC713200 | methyl (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-c
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Bardoxolone methyl is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2.Synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TN
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of Peroxisome proliferator-activated receptor-γ
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities.