bay 11-7085|196309-76-9|(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile|(E)-3-((4-(tert-Butyl)phenyl)sulfonyl)acrylonitrile|BAY 11-7083|bay11-7085|(E)-3-(4-tert-butylphenyl)sulfonylprop-2-enenitrile|BAY-117085|(E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitr
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Irreversibly inhibits TNF-α-induced IxBα phosphorylation. Reduces NF-κB and adhesion molecules (IC 50 = 5-10 μM). Anti-inflammatory, anti cancer and neuroprotective agent in vivo .
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Suenaga N et al.. (2019) Loss of Tumor Suppressor CYLD Expression Triggers Cisplatin Resistance in Oral Squamous Cell Carcinoma.. Int J Mol Sci, 20 (20):[PMID:31635163]
2.Fang H et al.. (2019) NF-?B signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage.. Cell Cycle, 18 (9):(1001-1018). [PMID:30990350]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
I2214561