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BAY-297 , CAS No.B607942, Inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

BAY-297 , CAS No.B607942, Inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Item Number

B607942

Grouped product items
SKU	Size	Availability	Price	Qty
B607942-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90
B607942-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	BAY297;compound 58
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	(2R)-2-[[2-[4-(3-chloro-2-fluorophenyl)phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide
INCHI	InChI=1S/C25H19ClFN5O/c1-2-20(25(29)33)31-24-17-10-11-30-13-21(17)32-23(18(24)12-28)15-8-6-14(7-9-15)16-4-3-5-19(26)22(16)27/h3-11,13,20H,2H2,1H3,(H2,29,33)(H,31,32)/t20-/m1/s1
InChi Key	LACMSNCHWBQXEK-HXUWFJFHSA-N
Canonical SMILES	Clc1c(c(ccc1)c1ccc(cc1)c1nc2cnccc2c(c1C#N)N[C@@H](C(=O)N)CC)F
PubChem CID	155884469

PubChem CID	155884469
RCSB PDB Ligand	P4Z

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1. Wortmann L, Bräuer N, Holton SJ, Irlbacher H, Weiske J, Lechner C, Meier R, Karén J, Siöberg CB, Pütter V et al.. (2021) Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.. J Med Chem, 129 (3): (589-97). [PMID:34699202]

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