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BAY 61-3606 , CAS No.B607948, Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of spleen associated tyrosine kinase

Moligand™

PubChem CID: 10200390

Item Number

B607948

Grouped product items
SKU	Size	Availability	Price	Qty
B607948-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
B607948-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

component of inhibitor of nuclear factor kappa B kinase complex Inhibitor mitogen-activated protein kinase kinase kinase kinase 2 Inhibitor spleen associated tyrosine kinase Inhibitor

Basic Description

Synonyms	BAY 61-3606\|732983-37-8\|BAY-61-3606 free base\|2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide\|Syk inhibitor IV\|BAY61-3606\|BAY 61-3606 free base\|61G8S0H9KX\|CHEMBL1190711\|BAY-613606\|3-Pyridinecarboxamide, 2-((7-(3,4-dime
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of component of inhibitor of nuclear factor kappa B kinase complex;Inhibitor of mitogen-activated protein kinase kinase kinase kinase 2;Inhibitor of spleen associated tyrosine kinase

Associated Targets

CDC7 Tchem Cell division cycle 7-related protein kinase 1 Activities

Discover Target: CDC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHUK Tchem Inhibitor of nuclear factor kappa-B kinase subunit alpha 1 Activities

Discover Target: CHUK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SYK Tclin Tyrosine-protein kinase SYK 3 Activities

Discover Target: SYK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K2 Tchem Mitogen-activated protein kinase kinase kinase kinase 2 2 Activities

Discover Target: MAP4K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NEK4 Tchem Serine/threonine-protein kinase Nek4 1 Activities

Discover Target: NEK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK4 Tchem Dual specificity protein kinase CLK4 1 Activities

Discover Target: CLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 1 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
InChi Key	JWQOJVOKBAAAAR-UHFFFAOYSA-N
Canonical SMILES	COc1cc(ccc1OC)c1nc(Nc2ncccc2C(=O)N)n2c(c1)ncc2
Isomeric SMILES	COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
PubChem CID	10200390

PubChem CID

10200390

ChEMBL Ligand

CHEMBL1190711

References

1. Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, Ishimori M, Nagai H, Li YF, Yura T et al.. (2003) The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.. J Pharmacol Exp Ther, 306 (3): (1174-81). [PMID:12766258]
2. Ho CM, Donovan-Banfield IZ, Tan L, Zhang T, Gray NS, Strang BL. (2016) Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells.. PLoS ONE, 11 (3): (e0150339). [PMID:26930276]

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