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BAY 61-3606 dihydrochloride - 98%, high purity , CAS No.648903-57-5
Basic Description Synonyms 648903-57-5|BAY 61-3606 dihydrochloride|BAY 61-3606 (dihydrochloride)|BAY-61-3606|96PPV9GQ7A|CHEMBL541400|BAY-61-3606 2HCl|2-((7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl)amino)nicotinamide dihydrochloride|2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c] Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
Product Properties ALogP 3.082 HBD Count 2 Rotatable Bond 6
Names and Identifiers Pubchem Sid 488197731 IUPAC Name 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride INCHI InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);2*1H InChi Key SPMFEULFGGPQLN-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl Isomeric SMILES COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl.Cl PubChem CID 11784504 Molecular Weight 463.32
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 14 mg/mL (30.21 mM); Water: Insoluble; Ethanol: Insoluble; Sensitivity Moisture sensitive DMSO(mg / mL) Max Solubility 14 DMSO(mM) Max Solubility 30.21669688 Water(mg / mL) Max Solubility ＜1
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D2320756