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Belinostat (PXD101) - ≥98%, high purity , CAS No.414864-00-9, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor

Specifications & Purity: ≥98%

CAS#: 414864-00-9
Formula: C₁₅H₁₄N₂O₄S
Molecular Weight: 318.35
PubChem CID: 6918638

Item Number

B126780

Grouped product items
SKU	Size	Availability	Price
B126780-10mg	10mg	In stock	$274.90
B126780-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$879.90
B126780-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,369.90

View related series

histone deacetylase 1 Inhibitor histone deacetylase 2 Inhibitor histone deacetylase 3 Inhibitor histone deacetylase 4 Inhibitor histone deacetylase 5 Inhibitor histone deacetylase 6 Inhibitor histone deacetylase 7 Inhibitor histone deacetylase 8 Inhibitor histone deacetylase 9 Inhibitor

Basic Description

Synonyms	Belinostat\|414864-00-9\|PXD101\|866323-14-0\|Belinostat (PXD101)\|Beleodaq\|PXD-101\|(E)-N-hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide\|E-Belinostat\|NSC726630\|PXD 101\|PX-105684\|N-HYDROXY-3-(3-PHENYLSULFAMOYLPHENYL)ACRYLAMIDE\|UNII-F4H96P17NZ\|F4H96P17NZ\|PX10
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 2;Inhibitor of histone deacetylase 3;Inhibitor of histone deacetylase 4;Inhibitor of histone deacetylase 5;Inhibitor of histone deacetylase 6;Inhibitor of histone deacetylase 7;Inhibitor

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 1 Activities

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC4 Tclin Histone deacetylase 4 6 Activities

Discover Target: HDAC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 10 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 12 Activities

Discover Target: HDAC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 5 Activities

Discover Target: HDAC7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC11 Tclin Histone deacetylase 11 1 Activities

Discover Target: HDAC11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC9 Tclin Histone deacetylase 9 5 Activities

Discover Target: HDAC9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 7 Activities

Discover Target: HDAC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC10 Tclin Histone deacetylase 10 1 Activities

Discover Target: HDAC10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 9 Activities

Discover Target: HDAC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 4 Activities

Discover Target: HDAC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 7 Activities

Discover Target: HDAC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
INCHI	InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
InChi Key	NCNRHFGMJRPRSK-MDZDMXLPSA-N
Canonical SMILES	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO
Isomeric SMILES	C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)/C=C/C(=O)NO
PubChem CID	6918638
Molecular Weight	318.35

PubChem CID

ChEMBL Ligand

ChEBI

Wikipedia

CAS Registry No.

DrugBank Ligand

RCSB PDB Ligand

PEP

Reactome Reaction

Reactome Drug

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2 results found

Lot Number	Certificate Type	Date	Item
L2219179	Certificate of Analysis	Jan 10, 2023	B126780
A1523058	Certificate of Analysis	Sep 13, 2022	B126780

References

1. Qian X, LaRochelle WJ, Ara G, Wu F, Petersen KD, Thougaard A, Sehested M, Lichenstein HS, Jeffers M. (2006) Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies.. Mol Cancer Ther, 5 (8): (2086-95). [PMID:16928830]
2. Buckley MT, Yoon J, Yee H, Chiriboga L, Liebes L, Ara G, Qian X, Bajorin DF, Sun TT, Wu XR et al.. (2007) The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo.. J Transl Med, 5 (3): (49). [PMID:17935615]
3. Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, La Thangue NB, Brown R. (2003) Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101.. Mol Cancer Ther, 2 (8): (721-8). [PMID:12939461]
4. Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. (2010) Chemical phylogenetics of histone deacetylases.. Nat Chem Biol, 6 (3): (238-243). [PMID:20139990]
5. Savickiene J, Treigyte G, Valiuliene G, Stirblyte I, Navakauskiene R. (2014) Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells.. Anticancer Drugs, 25 (8): (938-49). [PMID:24800886]
6. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N et al.. (2008) Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.. Biochem J, 409 (2): (581-9). [PMID:17868033]

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