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betrixaban - 97%, high purity , Coagulation factor X inhibitor, CAS No.330942-05-7, Coagulation factor X inhibitor

Moligand™
≥97%

CAS#: 330942-05-7
Formula: C₂₃H₂₂ClN₅O₃
Molecular Weight: 451.91
PubChem CID: 10275777

Item Number

B176153

Grouped product items
SKU	Size	Availability	Price
B176153-50mg	50mg	In stock	$355.90
B176153-250mg	250mg	In stock	$1,602.90
B176153-1g	1g	In stock	$5,767.90

View related series

coagulation factor X Inhibitor

Basic Description

Synonyms	Betrixaban\|330942-05-7\|PRT054021\|Bevyxxa\|N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide\|PRT 054021\|PRT-054021\|UNII-74RWP7W0J9\|Betrixaban [USAN]\|74RWP7W0J9\|N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)be
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 μM) and little potency against thrombin, trypsin,
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Coagulation factor X inhibitor
Product Description	Product Description： Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with IC50 of 1.5 nM

Associated Targets

F10 Tclin Coagulation factor X 6 Activities

Discover Target: F10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PROC Tchem Vitamin K-dependent protein C 0 Activities

Discover Target: PROC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLAT Tclin Tissue-type plasminogen activator 0 Activities

Discover Target: PLAT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLG Tclin Plasminogen 0 Activities

Discover Target: PLG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Prothrombin 1 Activities

Discover Target: F2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 3 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide
INCHI	InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31)
InChi Key	XHOLNRLADUSQLD-UHFFFAOYSA-N
Canonical SMILES	CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl
Isomeric SMILES	CN(C)C(=N)C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)OC)C(=O)NC3=NC=C(C=C3)Cl
PubChem CID	10275777
Molecular Weight	451.91

ChEMBL Ligand

PubChem CID

BindingDB Ligand

CAS Registry No.

Reactome Reaction

R-HSA-9015122, R-HSA-9015111

Reactome Drug

R-ALL-9038746

DrugCentral Ligand

5241

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
A2305119	Certificate of Analysis	Aug 31, 2022	B176153
A2305142	Certificate of Analysis	Aug 31, 2022	B176153
L2210342	Certificate of Analysis	Aug 31, 2022	B176153
L2210355	Certificate of Analysis	Aug 31, 2022	B176153
L2210358	Certificate of Analysis	Aug 31, 2022	B176153

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P319:Get medical help if you feel unwell.

References

1. Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T et al.. (2009) Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.. Bioorg Med Chem Lett, 19 (8): (2179-85). [PMID:19297154]

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