| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| B655815-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $110.90 |
| Specifications & Purity | 10mM in DMSO |
|---|---|
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | BI 99179 is a potent and selective type I fatty acid synthase ( FAS ) inhibitor with an IC 50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats In Vitro BI 99179 is potent in the mouse hypothalamic N-42 cell with an IC 50 of 0.6 μM. BI 99179 shows no significant LDH release in the cytotoxicity assay up to 30 μM. BI 99179 (BI-99179; 1, 2, and 4 µM) shows antiproliferative efficacy in human glioma GAMG cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Human glioma GAMG cells Concentration: 1, 2, 4 µM Incubation Time: 96 to 120 hours Result: The optimal palmitate concentration for GAMG cell line was 4 µM. In Vivo BI 99179 has a super pharmacokinetic profile in male Han/Wistar rats (oral application of 4 mg/kg) with half life (t 1/2 ) of 3.0 h . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 79 nM (FASN) |
| Canonical SMILES | O=C([C@H]1C[C@@H](NC(CC)=O)CC1)N(C2=CC=C(C3=NC4=CC=CC=C4O3)C=C2)C |
|---|---|
| Molecular Weight | 391.46 |
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